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Roscovitine

Roscovitine Structure
CAS No.
186692-46-6
Chemical Name:
Roscovitine
Synonyms
Seliciclib;Roscovitin;Roscovitine (Seliciclib,CYC202);CYC 202;Posiphe;CS-1845;P34 CDC2;ROSCOVITINE;Roscoviline;(R)-2-(1-ETHY
CBNumber:
CB0367185
Molecular Formula:
C19H26N6O
Molecular Weight:
354.45
MOL File:
186692-46-6.mol
MSDS File:
SDS
Modify Date:
2024/6/13 17:03:25
Request For Quotation

Roscovitine Properties

Melting point 106～107℃
Boiling point 577.5±60.0 °C(Predicted)
Density 1.3
storage temp. -20°C
solubility Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form White to off-white solid
pka 14.56±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference 186692-46-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
Safety Statements  22-24/25
WGK Germany  3
HS Code  29335990

Roscovitine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R7772 Roscovitine ≥98% (TLC) 186692-46-6 1MG ₹11463.68 2022-06-14 Buy
Sigma-Aldrich(India) R7772 Roscovitine ≥98% (TLC) 186692-46-6 5MG ₹38352.98 2022-06-14 Buy
Sigma-Aldrich(India) 557360 Roscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e 186692-46-6 1MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) 557360 Roscovitine - CAS 186692-46-6 - Calbiochem A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater e 186692-46-6 5MG ₹29990 2022-06-14 Buy
Product number Packaging Price Buy
R7772 1MG ₹11463.68 Buy
R7772 5MG ₹38352.98 Buy
557360 1MG ₹5880 Buy
557360 5MG ₹29990 Buy

Roscovitine Chemical Properties,Uses,Production

Definition

ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.

General Description

A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34cdk1 and p33cdk2 and twenty-fold greater efficacy towards p33cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.

Anticancer Research

Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).

Roscovitine Preparation Products And Raw materials

Raw materials

Preparation Products

Roscovitine Suppliers

Global( 218)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shanghai Gubang New Materail Technology Co. LTD 21-51317962 +8618721305404 CHINA 272 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25196 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Shanghai Gubang New Materail Technology Co. LTD 58
Dideu Industries Group Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58

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Roscovitine Spectrum

ROSCOVITINE(186692-46-6)1HNMR

186692-46-6(Roscovitine)Related Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Selumetinib Alisertib (MLN8237) Dasatinib PD 0332991 HCl
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PD0332991 Isethionate BML-259 NS-398 Roscovitine
SELICICLIB (S)-ROSCOVITINE S-ROSCOVITINE 98% (HPLC),ROSCOVITINE, (S)-ISOMER,(S)-ROSCOVITINE RS-ROSCOVITINE 98% (HPLC) (R)-ROSCOVITINE, >95%
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2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE ROSCOVITINE (R)-ROSCOVITINE (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE P34 CDC2 R-ROSCOVITINE 98% (HPLC) ROSCOVITINE 95+% 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)- 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (CYC202,Seliciclib) 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine(CYC202) 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]- (R)-2-(1-ETHY Roscovitine (Seliciclib) (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol CYC 202 Roscoviline Posiphe CYC-202(ROSCOVITINE) 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202) Roscovitine (R)-Roscovitine Roscovitine, >=98% Roscovitine - CAS 186692-46-6 - Calbiochem CS-1845 SELICICLIB (ROSCOVITINE) CYC202;R-ROSCOVITINE;SELICICLIB 2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol （CYC202) ROSCOVITINE USP/EP/BP Seliciclib-d7 Seliciclib Roscovitin Roscovitine (Seliciclib,CYC202) 186692-46-6 Cell Signaling and Neuroscience Cell Cycle Cell Cycle Regulators Cell Biology BioChemical Apoptosis and Cell Cycle Inhibitors Apis API intermediates