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4-(Bromomethyl)tetrahydropyran

4-(Bromomethyl)tetrahydropyran Structure
CAS No.
125552-89-8
Chemical Name:
4-(Bromomethyl)tetrahydropyran
Synonyms
4-(broMoMethyl)oxane;4-bromomethytetrahydropyran;4-(BroMoMethyl)tetrahydro...;4-BROMOMETHYLTETRAHYDROPYRAN;4-(Bromomethyl)tetrahydropyrane;4-Bromomethyltetrahydropyran, 96%;4-(Bromomethyl)tetrahydropyran ,97%;4-(BROMOMETHYL)-TETRAHYDRO-2H-PYRAN;2H-Pyran, 4-(broMoMethyl)tetrahydro-;Tetrahydro-2H-pyran-4-yl-MethylbroMide
CBNumber:
CB0436966
Molecular Formula:
C6H11BrO
Molecular Weight:
179.05
MOL File:
125552-89-8.mol
MSDS File:
SDS
Modify Date:
2025/3/10 21:40:31

4-(Bromomethyl)tetrahydropyran Properties

Boiling point 88 °C
Density 1.359±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
form liquid
color Light beige/brown
InChI InChI=1S/C6H11BrO/c7-5-6-1-3-8-4-2-6/h6H,1-5H2
InChIKey LMOOYAKLEOGKJR-UHFFFAOYSA-N
SMILES C1OCCC(CBr)C1
CAS DataBase Reference 125552-89-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  C,Xn
Risk Statements  36/37/38-34-22
Safety Statements  26-36/37/39-45-23
RIDADR  3265
Hazard Note  Irritant
HazardClass  8
PackingGroup 
HS Code  29339900
NFPA 704
1
3 0

4-(Bromomethyl)tetrahydropyran Chemical Properties,Uses,Production

Chemical Properties

Viscous liquid

Uses

4-(Bromomethyl)tetrahydropyran is an important organic synthesis intermediate, widely used in the fields of medicine, pesticides and dyes. It can be used to synthesize a variety of biologically active compounds, such as antibacterial agents, anti-tumor drugs, nervous system drugs and fluorescent dyes. In addition, 4-(Bromomethyl)tetrahydropyran can also be used to synthesize organic pigments and functional materials.

Synthesis

To a solution of Tetrahydropyran-4-methanol and N-bromobutanimide (NBS) in DCM was added PPh3 at 0°C. The reaction mixture was stirred at room temperature for 1–2h. The resulting mixture was washed with water (20mL) and brine (3×20mL). The organic layer was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2–5%) to give 4-(Bromomethyl)tetrahydropyran as a colorless oil.

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4-(BROMOMETHYL)-TETRAHYDRO-2H-PYRAN 4-BROMOMETHYLTETRAHYDROPYRAN 4-(Bromomethyl)tetrahydropyrane 4-(Bromomethyl)tetrahydropyran ,97% 4-(Bromomethyl)tetrahydro-2H-pyran 97% 4-bromomethytetrahydropyran Tetrahydro-2H-pyran-4-yl-MethylbroMide 4-(BroMoMethyl)tetrahydro... (Tetrahydro-2H-pyran-4-yl)methyl bromide, 4-(Bromomethyl)oxane 4-(broMoMethyl)oxane 2H-Pyran, 4-(broMoMethyl)tetrahydro- 1-(Tetrahydro-2H-pyran-4-yl)methylbromide 4-BROMOMETHYLTETRAHYDROPYRAN ISO 9001:2015 REACH 4-Bromomethyltetrahydropyran, 96% 125552-89-8 C6H11BrO Heterocyclic Compounds blocks Bromides Heterocycles Halides