Chloramphenicol palmitate
- CAS No.
- 530-43-8
- Chemical Name:
- Chloramphenicol palmitate
- Synonyms
- cap-p;detreopal;Chloropal;Chlorambon;cap-palmitate;Clorolifarina;chloromycetinpalmitate;CHLORAMPHENICOL PALMITATE;CHLORAMPHENICAL PALMITATE;Chloramphenicol Impurity 2
- CBNumber:
- CB0437291
- Molecular Formula:
- C27H42Cl2N2O6
- Molecular Weight:
- 561.54
- MOL File:
- 530-43-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:54:58
| Melting point | 90 C |
|---|---|
| alpha | D26 +24.6° (c = 5 in ethanol) |
| Boiling point | 691.6±55.0 °C(Predicted) |
| Density | 1.2354 (rough estimate) |
| refractive index | 1.7350 (estimate) |
| storage temp. | Store at RT. |
| solubility | DMSO (Slightly), Ethanol (Sparingly), Ethyl Acetate (Slightly) |
| pka | 10.69±0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 8.423ug/L(25 ºC) |
| λmax | 271nm(EtOH)(lit.) |
| Merck | 14,2077 |
| BRN | 2826438 |
| Stability | Hygroscopic |
| CAS DataBase Reference | 530-43-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P280 |
| Hazard Codes | Xn |
| Risk Statements | 40-36/37/38-20/21/22 |
| Safety Statements | 36/37-36-26 |
| WGK Germany | 3 |
| RTECS | RT4735000 |
| HS Code | 29414000 |
Chloramphenicol palmitate Chemical Properties,Uses,Production
Description
Chloramphenicol palmitate is an orally bioavailable ester prodrug form of the antibiotic chloramphenicol. It is hydrolyzed in the small intestine to release chloramphenicol. Formulations containing chloramphenicol palmitate were previously used in the treatment of severe bacterial infections.
Chemical Properties
white crystals
Uses
Chloramphenicol palmitate is prepared by acylation of chloramphenicol with palmitic acid. Although chloramphenicol palmitate is a more hydrophobic drug which should enhance bioavailability, the primary advantage of the ester is to mask the taste of chloramphenicol in oral formulations. Chloramphenicol palmitate is significantly less active than chloramphenicol but acts as a prodrug, being readily hydrolysed by acid and esterase in the gut to release chloramphenicol.
Application
Chloramphenicol palmitate was synthesized by Parke Davis Co. in 1952. It has a much less bitter taste than chloramphenicol and is suitable for oral administration, especially for children. The palmitate shows a higher serum level after oral administration than chloramphenicol does and acts the same as chloramphenicol in vivo.
General Description
Chloramphenicol palmitate is the palmitic acid ester ofchloramphenicol. It is a tasteless prodrug of chloramphenicolintended for pediatric use. The ester must hydrolyze invivo following oral absorption to provide the active form.Erratic serum levels were associated with early formulationsof the palmitate, but the manufacturer claims that thebioavailability of the current preparation is comparable tothat of chloramphenicol itself.
Safety Profile
Moderately toxic by oral route. An experimental teratogen. Other experimental reproductive effects. An antibiotic. When heated to decomposition it emits very toxic fumes of NOx and Cl-. See also other chloramphenicol entries.
Purification Methods
The palmitate crystallises from *benzene or xylene with m 105-106o and [] D –39.5o (c 2, Et2O), max 267.3nm. [Edgerton et al. J Am Chem Soc 77 27 1955, Beilstein 13 IV 2753.]
Chloramphenicol palmitate Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Mehta Pharmaceutical Industries | +91-8390068777 +91-8390068777 | Mumbai, India | 30 | 58 | Inquiry |
| Anuh Pharma Ltd (SK GROUP) | +912266227575 | Maharashtra, India | 38 | 58 | Inquiry |
| Mehta API Pvt. Ltd. | +91-9920552082 +91-9920552082 | Maharashtra, India | 33 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| ShreeGen Pharma Ltd (part of Rumit Group of Companies) | +91-4023869399 +91-9664830616 | Telangana, India | 25 | 58 | Inquiry |
| Urmila Chemopharma | +91-9819537618 +91-8928751722 | Maharashtra, India | 25 | 58 | Inquiry |
| Century Pharmaceuticals Ltd | +91-2652361581 +91-2652361581 | Gujarat, India | 53 | 58 | Inquiry |
| Ishita Drugs And Industries Ltd | +91-7226995614 +91-7226995613 | Telangana, India | 47 | 58 | Inquiry |
| Innorex Pharmaceuticals Private Limited | 91-22-28560031 | Maharashtra, India | 173 | 58 | Inquiry |
| Aara Exim Private Limited | +91-79-2685 5862 | Gujarat, India | 5 | 58 | Inquiry |
530-43-8(Chloramphenicol palmitate)Related Search:
1of4
chevron_right