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Barnidipine hydrochloride

CAS No.: 104757-53-1

Chemical Name:: Barnidipine hydrochloride

Synonyms: ym730;Hypoca;ly198561;ym09730-5;Mepirodipine;BARNIDIPINE HCL;YM-09730-5：Hypoca;BARNIDIPINE HYDROCHLORIDE;mepirodipinehydrochloride;Barnidipine Hydrochloride l

CBNumber:: CB1397277

Molecular Formula:: C27H30ClN3O6

Molecular Weight:: 528

MOL File:: 104757-53-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:00

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Barnidipine hydrochloride Properties

Melting point	223-226°C
alpha	D20 +116.4° (c = 1 in methanol)
storage temp.	Sealed in dry,Room Temperature
solubility	insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO with gentle warming
form	A crystalline solid
color	Light yellow to yellow
CAS DataBase Reference	104757-53-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H319

Precautionary statements

P280-P305+P351+P338

Toxicity

LD50 orally in male, female rats: 105, 113 mg/kg (Satoh)

NFPA 704

	0
2		0

Barnidipine hydrochloride Chemical Properties,Uses,Production

Description

Barnidipine hydrochloride, chemically known as (3S)-1-benzyl-3-pyrrolidinylmethyl-(4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride, is a new long-acting dihydropyridine calcium antagonist developed and marketed by Yamanouchi Pharmaceutical (now Astellas Pharma). This medication effectively lowers blood pressure without impacting heart rate by specifically targeting calcium channels responsible for transmembrane potential. By inhibiting calcium influx into cells, it selectively relaxes smooth muscle in peripheral and coronary blood vessels.

Chemical Properties

Pale Yellow Solid. Melting point 226-228°C. [α]D20+116.4° (C=1, methanol). Insoluble in water. Acute toxicity LD50 male and female rats (mg/kg): 105, 113 Oral.

Uses

Barnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of primary hypertension and renal hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine.

Definition

ChEBI: Barnidipine hydrochloride is a dihydropyridine. 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. It is a potential candidate in the treatment of patients with renal parenchymal hypertension.

Biological Activity

Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used as a treatment for hypertension.

References

[1] WEGENERJ W. Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes.[J]. British Journal of Pharmacology, 2000. DOI:10.1038/sj.bjp.0703514.
[2] ALP YILDIRIMF ILKAY. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.[J]. European journal of pharmacology, 2015. DOI:10.1016/j.ejphar.2015.07.033.
[3] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:10.3390/molecules19011344.

Barnidipine hydrochloride Preparation Products And Raw materials

Raw materials

Barnidipine Isopropyl alcohol trans-Methyl crotonate Pyrrolidine 3-Nitrobenzaldehyde

1-BENZYL-3-ACETOACETYLOXYPYRROLIDINE

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Preparation Products

Barnidipine hydrochloride Suppliers

Global( 122)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21676	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	China	14198	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
WinWin Chemical CO., Limited	58
Shaanxi Dideu Medichem Co. Ltd	58

Barnidipine hydrochloride Spectrum

Barnidipine(104757-53-1)¹HNMR

104757-53-1(Barnidipine hydrochloride)Related Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate N,N-Dimethylformamide Benzyl nicotinate ETHANE N-Methyl-2-pyrrolidone

Benzyl alcohol Topotecan hydrochloride Benzyl isocyanate Benzyl chloride Nicardipine hydrochloride

Dimethyl fumarate Benzyl benzoate Dimethyl sulfoxide 2,5-Dimethylpyrrolidine Polyvinylpyrrolidone

(S)-1-Benzyl-3-pyrrolidinol Benzyl N-Benzyl-3-pyrrolidinol

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hydrochloride,(s-(r*,r*))-hyl1-(phenylmethyl)-3-pyrrolidinyleste ly198561 BARNIDIPINE HCL BARNIDIPINE HYDROCHLORIDE (+)-(3's,4s)-1-benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, (4S)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, [S-(R*,R*)]- Hypoca Mepirodipine 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, (4S)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, [S-(R*,R*)]- YM-09730-5：Hypoca (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride [S-( R^<*>^，R^<*>^)]-1，4-Dihydro-2，6-dimethyl-4-(3-nitrophenyl)-3，5-pyridinedicarboxylic acid methy11-(phenylmethyl)-3-pyrrolidinyl ester mepirodipinehydrochloride ym09730-5 3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3 ym730 3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (4S)-1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-[(3S)-1-(phenylMethyl)-3-pyrrolidinyl] Ester Hydrochloride [S-(R*,R*)]-1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 1-(PhenylMethyl)-3-pyrrolidinyl Ester Monohydrochloride Barnidipine Hydrochloride l 3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-d 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, hydrochloride (1:1), (4S)- 2,6-dimethyl-4-(3-nitrophenyl)-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid O3-methyl ester O5-(3-pyrrolidinyl) ester hydrochloride Barnidipine D5 HydrochlorideQ: What is Barnidipine D5 Hydrochloride Q: What is the CAS Number of Barnidipine D5 Hydrochloride Q: What is the storage condition of Barnidipine D5 Hydrochloride Q: What are the applications of Barnidipine D5 Hydrochloride 104757-53-1 C27H29N3O6HCl52801 C27H29N3O6HCl C27H29N3O6 C27H30ClN3O6 C27H28N3O6 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API Heterocycle-Pyridine series