L-Theanine

L-Theanine Properties

Melting point	207°C
Boiling point	430.2±40.0 °C(Predicted)
Density	1.171±0.06 g/cm3(Predicted)
refractive index	8 ° (C=5, H2O)
storage temp.	2-8°C
solubility	Soluble in Water (up to 20 mg/ml).
pka	2.24±0.10(Predicted)
form	powder
color	White
Odor	Odorless
Water Solubility	almost transparency
Stability	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
InChI	InChI=1S/C7H14N2O3/c1-2-9-5(7(11)12)3-4-6(8)10/h5,9H,2-4H2,1H3,(H2,8,10)(H,11,12)/t5-/m0/s1
InChIKey	DATAGRPVKZEWHA-YFKPBYRVSA-N
SMILES	C(O)(=O)[C@H](CCC(N)=O)NCC
LogP	-0.661 (est)
CAS DataBase Reference	3081-61-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280-P302+P352
Hazard Codes	Xi
Risk Statements	43
Safety Statements	28-36/37
HS Code	29241990
Hazardous Substances Data	3081-61-6(Hazardous Substances Data)

L-Theanine price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SMB00395	L-Theanine ≥98% (HPLC)	3081-61-6	100MG	₹13368.88	2022-06-14	Buy
Sigma-Aldrich(India)	SMB00395	L-Theanine ≥98% (HPLC)	3081-61-6	500MG	₹52771.88	2022-06-14	Buy
TCI Chemicals (India)	T0954	L-Theanine	3081-61-6	1G	₹7700	2022-05-26	Buy
TCI Chemicals (India)	T0954	L-Theanine	3081-61-6	5G	₹9800	2022-05-26	Buy
SRL	44826	L-Theanine extrapure, 99%	3081-61-6	1Gms	₹840	2022-05-26	Buy

Product number	Packaging	Price	Buy
SMB00395	100MG	₹13368.88	Buy
SMB00395	500MG	₹52771.88	Buy
T0954	1G	₹7700	Buy
T0954	5G	₹9800	Buy
44826	1Gms	₹840	Buy

L-Theanine Chemical Properties,Uses,Production

Description

L-Theanine is the major amino acid found in Camellia sinensis, the source of green tea. It is an analog of the excitatory neurotransmitter, glutamate, and thusly, binds to glutamate receptors. L-Theanine can antagonize various glutamate receptor subtypes as well as inhibit glutamine and glutamate transporters, which has been shown to be neuroprotective in animal models of focal cerebral ischemia. Further, L-theanine is reported to increase brain levels of dopamine, serotonin, GABA, nerve growth factor, and brain-derived neurotrophic factor.

Chemical Properties

White Crystalline Solid

Uses

L-Theanine is a safe and non-toxic photogenic food supplement.
It has been studied as a food additive and functional food in relation to human nutrition.
It has noticeable bioactivities including anti-cerebral ischemia-reperfusion injury, stress-reducing, antitumor, anti-aging, and anti-anxiety activities.

Definition

ChEBI: L-Theanine is a N(5)-alkylglutamine where the alkyl group is ethyl. It has been isolated from green tea. It has a role as a neuroprotective agent, a plant metabolite and a geroprotector. It is a tautomer of a N(5)-ethyl-L-glutamine zwitterion.

benefits

L-Theanine is one of the active ingredients in green tea. It has a variety of physiological functions such as protecting nerves, lowering blood pressure, antioxidant, regulating immune response, improving cognitive ability and calming the mind. Therefore, L-Theanine helps to improve concentration and cognitive ability, improve immune function, reduce stress, relieve anxiety and depression symptoms, and improve sleep. In addition, studies have shown that L-Theanine also helps to alleviate symptoms in patients with high blood pressure and reduces the risk of pancreatic cancer in women.

Biological Activity

Amino acid analog of glutamine and component of green tea. Shown to bind to AMPA, Kainate, NMDA and group I mGlu receptors. Displays neuroprotective effects in vivo . Promotes self-renewal of human embryonic stem cells (hESC).

Side effects

Side effects have not been reported. But drinking too much tea may cause: Headaches; Trouble staying asleep; Nausea (feeling like you are going to throw up); Irritability; Stomach pain

Synthesis

Theanine was first chemically synthesised in 1942 by Lichtenstein^[28]with a yield of 90 g kg^-1 by treating pyrrolidone-5-carboxylic acid with aqueous ethylamine for 20 days at 37 ℃. A number of other synthetic approaches have since been developed including a large-scale production method involving the reaction of γ-benzyl glutamate in the presence of trityl chloride and ethylamine [339 g kg^-1]^[29]and a two-step approach involving initial dehydration of L-glutamic acid to L-pyrrolidone carboxylic acid followed by ring opening in the presence of ethylamine to yield theanine [374 g kg^-1]^[30]. More recently, theanine was produced in four steps starting from commercially available N-phthaloyl-L-glutamic acid, which was dehydrated to the corresponding cyclic anhydride by reaction with acetic anhydride and then the ring was opened by reaction with ethylamine. Subsequent de-protection of the amine unit with hydrazine hydrate gave theanine with a 700 g kg^-1 overall yield^[31].
In the tea plant, theanine is bio-synthesised from glutamic acid and ethylamine by the enzyme theanine synthetase. However, the enzyme is very labile and cannot be used to produce the amino acid in commercial quantities^[32]. Therefore, other methods for the enzymatic synthesis of theanine have been developed using bacterial enzymes such as glutaminase, glutamine synthetase and γ-glutamyl-transpeptidase.

Drug interactions

There is some evidence L-theanine supplements may lower blood pressure. If you take one or more medications to lower blood pressure, you may want to avoid taking L-theanine. Due to its relaxing and sleep-supporting effects, L-theanine may also have an additive effect with some sedative medications. Avoid taking supplements containing D-theanine as it may prevent the absorption of L-theanine in the body.

Source

The tropical and temperate regions of Asian, African, South American countries are considered the main origin of tea plant [C. sinensis or Thea sinensis]. It is a member of Theaceae family. The majority members of Theaceae family are obtained from India, Sri Lanka, China, and Japan. The physiological properties and colour e.g. black, white, green, yellow or oolong tea strongly depends upon the degree of fermentation and processing conditions^[20]. L-theanine is mainly derived from a non-edible mushroom of Xerocomus badius, and C. sinensis. It is an amino acid which accumulates in the leaves of tea like C. sasanqua and C. japonica^[21]. In tea, L-theanine is responsible for a strong smell [aroma]in general and in particular it is linked with tea umami taste^[22]. From the compositional viewpoint, L-theanine comprises approximately 50% of the tea contents. Whereas, the dry tea contains 1-3% of L-theanine only, this higher or lower ratio of L-theanine can vary depending on several factors i.e. cultivation zone, production season, processing techniques, class of tea, time and type of harvest, etc^[27]. Additionally, the harvested tea at the beginning of summer is reported to have more theanine compared with tea harvested in late summer^[27]. Moreover, L-theanine concentration also depends on the type/class of tea. According to one study, a specific type of C. sinensis var. Sinensis has more L-theanine contents as compared to the C. sinensis var. Assamica^[23].

L-Theanine Preparation Products And Raw materials

Raw materials

DL-Pyroglutamic acid Ethylamine

Preparation Products

L-Theanine Suppliers

Global( 774)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3753	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6768	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4315	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6088	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Globex Enterprises	08048372402Ext 353	Delhi, India	44	58	Inquiry
A M Nutratech Private Limited	08048972593	Delhi, India	32	58	Inquiry
Solitude Global Impex	08048371882Ext 788	Delhi, India	17	58	Inquiry
Innovative	07942565925	Mumbai, India	617	58	Inquiry
A.M Group	08069013895Ext 133	Delhi, India	48	58	Inquiry

Supplier	Advantage
JSK Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Sisco Research Laboratories Pvt. Ltd.	58
Triveni chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Globex Enterprises	58
A M Nutratech Private Limited	58
Solitude Global Impex	58
Innovative	58
A.M Group	58

L-Theanine Spectrum

L-Theanine(3081-61-6)MS L-Theanine(3081-61-6)¹HNMR L-Theanine(3081-61-6)IR1 L-Theanine(3081-61-6)IR2 L-Theanine(3081-61-6)Raman

3081-61-6(L-Theanine)Related Search:

Ethyl formate Ethylparaben L-Glutamic acid L-Glutamine Ethyl acrylate

Ethyl cyanoacetate Citric acid L-Alanyl-L-Glutamine Folic acid Boc-D-Glutamine

Glycyl-L-glutamine monohydrate Transglutaminase Ethyl 2-(Chlorosulfonyl)acetate Ethanol 6-Amino-4-hydroxy-2-naphthalenesulfonic acid

Ethyl acetate ISOXADIFEN-ETHYL Glutamic acid

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