ChemicalBook > Product Catalog >API >Antineoplastic agents >Antimetabolites, Antineoplastic >Clofarabine
Clofarabine
- CAS No.
- 123318-82-1
- Chemical Name:
- Clofarabine
- Synonyms
- 200mg;Clolar;2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine;2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine;CAFDA; Clola;Evoltra;CS-1954;Clofarex;Clorabine
- CBNumber:
- CB2277491
- Molecular Formula:
- C10H11ClFN5O3
- Molecular Weight:
- 303.68
- MOL File:
- 123318-82-1.mol
- Modify Date:
- 2024/7/24 13:33:21
| Melting point | 228-2310C |
|---|---|
| Boiling point | 550.0±60.0 °C(Predicted) |
| Density | 1.4804 (estimate) |
| RTECS | UD7473000 |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | Powder |
| pka | 12.56±0.70(Predicted) |
| color | white |
| λmax | 263nm(EtOH)(lit.) |
| Merck | 14,2372 |
| InChIKey | INHHKRVRRUIAPA-KJHIFWANSA-N |
| CAS DataBase Reference | 123318-82-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 | |||||||||
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Clofarabine price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C7495 | Clofarabine ≥98% (HPLC) | 123318-82-1 | 5MG | ₹11387.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C7495 | Clofarabine ≥98% (HPLC) | 123318-82-1 | 25MG | ₹45865.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2500 | Clofarabine | 123318-82-1 | 20MG | ₹2600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2500 | Clofarabine | 123318-82-1 | 100MG | ₹6400 | 2022-05-26 | Buy |
Clofarabine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Clofarabine has been used in a cell viability assay to analyze the sensitivity of the isogenic cell lines towards clofarabine. It is also used to study the interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein.
Definition
ChEBI: A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metaboli e, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia.
Biological Activity
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Clofarabine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 449)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
123318-82-1(Clofarabine)Related Search:
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2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
CLOFARABINE
CAFDA
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE
5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
6-AMino-2-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
Clola
2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
CLOFARABINE(FORR&DONLY)
CLOFARABINE, 5-(6-AMINO-2-CHLORO-PURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL
CLORFARABINE
(2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE (CLOFARABINE)
2-Chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purin-6-amine
50MG/200MG/100G
2-Chloro-6-aMino-purine-2'-fluoro-2'- deoxy arabin
(2R,3R,4S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxyMethyl)oxolan-3-ol
Clofarabine, Free Base
Clofarex
Evoltra
6-Amino-2-chloro-9-(2'-deoxy-2'-fluoro-b-D-arabinofuranosyl)purine
CLOLAR CLOFARABINE
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-Chloro-2-arabino-fluoro-2-deoxyadenosine
6-AMino-2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
Clofarabine-13C1-15N3
CS-1954
Clofarabine >
(2R,3R,4S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
6-Amino-2-chloropurine -9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside, clofarabine
6-Amino-2-chloropurine-9-β-D-(2’-deoxy-2’-fluoro)arabinoriboside
Clofarabine USP/EP/BP
Antitumor drugs Clofarabine
ClofarabineQ: What is
Clofarabine Q: What is the CAS Number of
Clofarabine Q: What is the storage condition of
Clofarabine Q: What are the applications of
Clofarabine
9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
Clofarabine, 98%, a ribonucleotide reductase inhibitor
2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
Clolar
200mg
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Clorabine
Clofarabine (100 mg)
Precision Clofarabine
123318-82-1
23318-82-1
C10H11ClFN5O3
Antineoplastic
Anti-cancer&immunity
Pharmaceutical intermediate
CLOLAR
Bases & Related Reagents
Nucleotides
Inhibitors
Intermediates & Fine Chemicals