Nefiracetam
- CAS No.
- 77191-36-7
- Chemical Name:
- Nefiracetam
- Synonyms
- DMMPA;dmppa;dm9384;DZL-221;Translon;NEFIRACETAM;Nefiracetam>Nefiracetam powder;Nefiracetam (DM9384;Racetam Nefiracetam
- CBNumber:
- CB2416333
- Molecular Formula:
- C14H18N2O2
- Molecular Weight:
- 246.3
- MOL File:
- 77191-36-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/5 14:23:06
| Melting point | 151-155°C |
|---|---|
| Boiling point | 458.5±33.0 °C(Predicted) |
| Density | 1.187±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >5mg/mL |
| pka | 13.77±0.70(Predicted) |
| form | solid |
| color | white to off-white |
| Merck | 14,6439 |
| InChI | InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17) |
| InChIKey | NGHTXZCKLWZPGK-UHFFFAOYSA-N |
| SMILES | N1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O |
| CAS DataBase Reference | 77191-36-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UX9655650 | |||||||||
| HS Code | 2933.79.1500 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982) | |||||||||
| NFPA 704 |
|
Nefiracetam price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N2288 | Nefiracetam solid | 77191-36-7 | 50MG | ₹17731.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N2288 | Nefiracetam solid | 77191-36-7 | 250MG | ₹64636.08 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0996 | Nefiracetam | 77191-36-7 | 200MG | ₹8700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0996 | Nefiracetam | 77191-36-7 | 1G | ₹17500 | 2022-05-26 | Buy |
Nefiracetam Chemical Properties,Uses,Production
Uses
Nefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
Biological Activity
Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .
Mechanism of action
The mechanisms of nefiracetam seem to be linked back to two pathways. One of these pathways prolongs the opening of calcium channels (tied into PKA and a Gi/o protein), which enhances the signalling of a receptor independent of the synapse. The other pathway seems to be tied into PKC and CAMKII, which then augments signalling through cholinergic receptors (which then releases most excitatory neurotransmitters from the presynaptic level, like nicotine). The former pathway (calcium channels) appears critical for long-term potentiation, whereas the latter pathway (PKC/CAMKII) appears vital for neuronal signal enhancement. Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.
Nefiracetam Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | China | 300 | 58 | Inquiry |
| Hubei Langyou International Trading Co., Ltd | +8618874586545 | China | 197 | 58 | Inquiry |
| Wuhan senwayer century chemical Co.,Ltd | +undefined-27-86652399 +undefined13627115097 | China | 888 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 | China | 419 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
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