Tegafur
- CAS No.
- 17902-23-7
- Chemical Name:
- Tegafur
- Synonyms
- riol;afur;lamar;lifril;FENTAL;EXONAL;FT-207;fulaid;neberk;Fluaid
- CBNumber:
- CB2419051
- Molecular Formula:
- C8H9FN2O3
- Molecular Weight:
- 200.17
- MOL File:
- 17902-23-7.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 171-173 °C(lit.) |
|---|---|
| Density | 1.3222 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: >50mg/mL |
| form | Very Fine Crystalline Powder |
| pka | 7.63±0.10(Predicted) |
| color | white to off-white |
| Merck | 14,9112 |
| InChIKey | WFWLQNSHRPWKFK-UHFFFAOYSA-N |
| CAS DataBase Reference | 17902-23-7(CAS DataBase Reference) |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)- (17902-23-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YR0450000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 900 orally (3 days) (Yasumoto); 750 i.p. (FR 1574684), also reported as 1150 i.p. (Smart) | |||||||||
| NFPA 704 |
|
Tegafur price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T7205 | Tegafur ≥98% (HPLC), powder | 17902-23-7 | 5MG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7205 | Tegafur ≥98% (HPLC), powder | 17902-23-7 | 25MG | ₹38829.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0635 | 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil | 17902-23-7 | 5G | ₹4500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0635 | 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil | 17902-23-7 | 25G | ₹8800 | 2022-05-26 | Buy |
Tegafur Chemical Properties,Uses,Production
Description
Tegafur is an orally bioavailable prodrug form of 5-fluorouracil (5-FU; ). It is converted to 5-FU in vivo enzymatically or by cytochrome P450 oxidation. Tegafur inhibits proliferation of HT-29, BxPC-3, and Panc02 cells (IC50s = 201, 172, and 179 μM, respectively). It also reduces tumor growth in an HT-27 colon carcinoma mouse xenograft model when administered at a dose of 50 mg/kg and in a 4-1ST gastric carcinoma mouse xenograft model when used in combination with uracil. Formulations containing tegafur, in combination with uracil, have been used in the treatment of cancer.
Chemical Properties
White Crystalline Powder
Uses
Isotope labelled Tegafur (T013900), used as an antineoplastic.
Safety Profile
Poison by ingestion. Moderately toxic to humans by intravenous route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. Experimental teratogenic data. Human systemic effects: nausea and vomiting. Experimental reproductive effects. Questionable human carcinogen producing gastrointestinal tumors. Human mutation data reported. Used as an anti-cancer agent. When heated to decomposition it emits very toxic fumes of Fand NOx.
Tegafur Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Rely Chem | 08068441141Ext 305 | Mumbai, India | 125 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Cipla Ltd. | 91-22-24826000 | Maharashtra, India | 72 | 58 | Inquiry |
| bm chemie | 08048250160Ext 924 | Mumbai, India | 82 | 58 | Inquiry |
| Merit International | 91-22-40150081 | Maharashtra, India | 226 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| MANGALAM DRUGS AND ORGANICS LIMITED | 08147509329 | Uttar Pradesh, India | 50 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Cipla Ltd | 58 |
| Sakar Healthcare | 58 |
| Rely Chem | 58 |
| Clearsynth Labs | 58 |
| Cipla Ltd. | 58 |
| bm chemie | 58 |
| Merit International | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| MANGALAM DRUGS AND ORGANICS LIMITED | 58 |