ALAMETHICIN
- CAS No.
- 59588-86-2
- Chemical Name:
- ALAMETHICIN
- Synonyms
- f-50;U-22324;ALMETHICIN;ALAMETHICIN;ALAMETHACIN;alamethicini;alamethicinf30;alamethicingamma;ANTIBIOTIC U-22324
- CBNumber:
- CB2423618
- Molecular Formula:
- C92H150N22O25
- Molecular Weight:
- 1964.31
- MOL File:
- 59588-86-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
ALAMETHICIN Chemical Properties,Uses,Production
Uses
Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.
Enzyme inhibitor
These voltage-dependent, channel-forming, peptaibol antibiotics (MWAlamethicin F-30 = 1964.40; CAS 27061-78-5) from the soil fungus Trichoderma viride NRRL 3199 are membrane-active oligopeptides isolated from that exhibit anti-bacterial and anti-fungal properties. Peptaibols are amphipathic, usually highly helical in structure, and typically form voltage dependent ion channels that uncouple oxidative phosphorylation, often attended by in bacterial and fungal cell death. Alamethicin F-30 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib- Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phe-OH; Alamethicin F- 50 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly- Leu-Aib-Pro-Val-Aib Aib-Gln-Gln-Phe-OH; and Alamethicin II has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Val-Aib-Gly-Leu-Aib- Pro-Val-Aib-Aib-Glu-Gln-Phe-OH. Note: The name “peptaibol” is derived from the prefix “pep-“, the central syllable “aib”, and the suffix “-ol” to designate its peptide structure, the presence of an a-aminoisobutyryl unit, and the C-terminal alcohol.
ALAMETHICIN Preparation Products And Raw materials
Raw materials
Preparation Products
ALAMETHICIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chem-Impex International, Inc. | 800 869-9290 US and Canada only | United States | 6740 | 64 | Inquiry |
| IRIS Biotech GmbH | +49 9231 9619 73 | Germany | 4427 | 68 | Inquiry |
| BIOMOL INTERNATIONAL, LP | (800) 942-0430 | United States | 1503 | 77 | Inquiry |
| Alexis Corporation | +41 61 926 8989 | Switzerland | 3599 | 74 | Inquiry |
| A.G. Scientific, Inc. | 858 452 9925 | United States | 1066 | 71 | Inquiry |
| Fluorochem Ltd. | +44 1457 868921 | United Kingdom | 6406 | 74 | Inquiry |
| SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6913 | 91 | Inquiry |
| MP Biomedicals, Inc. | 949 833 2500 | United States | 6566 | 81 | Inquiry |
| cfm Oskar Tropitzsch | +49 9231961928 | Germany | 1136 | 62 | Inquiry |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Chem-Impex International, Inc. | 64 |
| IRIS Biotech GmbH | 68 |
| BIOMOL INTERNATIONAL, LP | 77 |
| Alexis Corporation | 74 |
| A.G. Scientific, Inc. | 71 |
| Fluorochem Ltd. | 74 |
| SIGMA-RBI | 91 |
| MP Biomedicals, Inc. | 81 |
| cfm Oskar Tropitzsch | 62 |