4-Chloro-3,5-dimethylphenol

4-Chloro-3,5-dimethylphenol Properties

Melting point	114-116 °C(lit.)
Boiling point	246 °C
Density	0.67 g/cm3
refractive index	1.5523 (estimate)
Flash point	132 °C
storage temp.	2-8°C
solubility	methanol: soluble1g/10 mL, clear to faintly turbid, colorless to very faintly yellow
pka	9.76±0.23(Predicted)
form	Crystalline Powder or Crystals
color	White to light beige
PH	7 (0.2g/l, H2O)
Odor	wh. cryst. or cryst. powd., char. phenolic odor
Water Solubility	0.3 g/L (20 ºC)
Merck	14,2176
BRN	1862539
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	OSDLLIBGSJNGJE-UHFFFAOYSA-N
LogP	3.270
CAS DataBase Reference	88-04-0(CAS DataBase Reference)
NIST Chemistry Reference	Chloroxylenol(88-04-0)
EPA Substance Registry System	4-Chloro-3,5-dimethylphenol (88-04-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H317-H319

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-36/38-43

Safety Statements

24-37

RIDADR

UN 3077 9/PG 3

WGK Germany

1

RTECS

ZE6850000

Hazard Note

Irritant

TSCA

Yes

HazardClass

9

PackingGroup

III

HS Code

29081000

Toxicity

LD50 orally in Rabbit: 3830 mg/kg

NFPA 704

	0
2		0

4-Chloro-3,5-dimethylphenol price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C38303	4-Chloro-3,5-dimethylphenol 99%	88-04-0	100G	₹1948.5	2022-06-14	Buy
Sigma-Aldrich(India)	PHR1478	Chloroxylenol Pharmaceutical Secondary Standard; Certified Reference Material	88-04-0	500MG	₹9926.53	2022-06-14	Buy
Sigma-Aldrich(India)	C38303	4-Chloro-3,5-dimethylphenol 99%	88-04-0	500G	₹4459.9	2022-06-14	Buy
Sigma-Aldrich(India)	8.18734	4-Chloro-3,5-dimethylphenol for synthesis	88-04-0	250G	₹9400	2022-06-14	Buy
Sigma-Aldrich(India)	24380	4-Chloro-3,5-dimethylphenol purum, ≥98.0% (T)	88-04-0	50G	₹1677.88	2022-06-14	Buy

Product number	Packaging	Price	Buy
C38303	100G	₹1948.5	Buy
PHR1478	500MG	₹9926.53	Buy
C38303	500G	₹4459.9	Buy
8.18734	250G	₹9400	Buy
24380	50G	₹1677.88	Buy

4-Chloro-3,5-dimethylphenol Chemical Properties,Uses,Production

Chemical Properties

4-Chloro-3,5-dimethylphenol is white or cream crystalline powder with a characteristic odour

Uses

4-Chloro-3,5-dimethylphenol is an antiseptic and germicide. Chloroxylenol is used for mildew prevention. Chloroxylenol is also an antibacterial; antiseptic (topical and urinary).

Production Methods

Chloroxylenol is prepared by treating 3,5-dimethylphenol with chlorine or sulfuryl chloride (SO₂Cl₂).

General Description

The degradation of 4-chloro-3,5-dimethylphenol (PCMX) by Fenton-like process using nanoparticulate zero-valent iron (nZVI) and hydrogen peroxide (H₂O₂) was studied.

Pharmaceutical Applications

4-Chloro-3,5-dimethylphenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection.
As a pharmaceutical excipient, 4-Chloro-3,5-dimethylphenol is commonly used in low concentrations as an antimicrobial preservative in topical formulations such as creams and ointments. 4-Chloro-3,5-dimethylphenol is also used in a number of cosmetic formulations.
Therapeutically, 4-Chloro-3,5-dimethylphenol has been investigated as a treatment for acne vulgaris, for treating infected root canals, and as an antifungal agent when impregnated into medical devices. 4-Chloro-3,5-dimethylphenol is included in drug products approved for topical antifungal, topical acne and topical dandruff/seborrheic dermatitis/psoriasis treatments.

Agricultural Uses

Microbiocide: 4-Chloro-3,5-dimethylphenol was first registered in the U.S. for use as a fungicide and is now applied as an antimicrobial for control of bacteria, algae and fungi in adhesives, emulsions, paints and wash tanks. It is registered for use in household and domestic dwellings, laundry equipment, bathrooms, diaper pails and in industrial water and aqueous systems. Not listed for use in EU countries. Registered for use in the U.S. There are 64 global suppliers.

Trade name

BAR-FUNGAL PLUS®[C]; BIO SLIME®[C]; DESSON®; DETTOL®; ECOTRU®; ESPADOL®; HUSEPT®; HUSEPT EXTRA®; NIPACIDE®; OTTASEPT®[C]; OTTASEPT® EXTRA[C]; PCMX; RBA 777®

Clinical Use

p-Chloro-m-xylenol (PC-MX; Metasep) is a nonirritating antiseptic agent with broad-spectrum antibacterial and antifungal properties. It is marketed in a 2% concentration as a shampoo. It has also been used topically for the treatment of tinea (ringworm) infections such as athlete s foot (tinea pedis) and jock itch (tinea cruris).

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. An eye irritant. An antimicrobial agent. See also CHLOROPHENOLS and CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic fumes of Cl-.

Safety

Chloroxylenol is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient in topical products. However, chloroxylenol has been placed in Toxicity Category I for eye irritation effects. In addition, allergic skin reactions have been reported. Taken orally, chloroxylenol is mildly toxic and ingestion of a chloroxylenol-containing disinfectant product has been associated with reports of fatal or severe instances of selfpoisoning.
LD₅₀ (mouse, IP): 0.115 g/kg
LD₅₀ (rat, dermal): >2.0 g/kg
LD₅₀ (rat, oral): 3.83 g/kg

storage

Chloroxylenol is stable at normal room temperature, but is volatile in steam. Contact with natural rubber should be avoided. Aqueous solutions of chloroxylenol are susceptible to microbial contamination and appropriate measures should be taken to prevent contamination during storage or dilution. Chloroxylenol should be stored in polyethylene, mild steel or stainless steel containers, which should be well-closed and kept in a cool, dry place. Chloroxylenol does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours.

Purification Methods

Crystallise the phenol from *benzene or toluene. [Beilstein 6 IV 3152.]

Incompatibilities

4-Chloro-3,5-dimethylphenol has been reported to be incompatible with nonionic surfactants and methylcellulose.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic preparations; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK. Approved in Europe as a preservative in cosmetics with a maximum authorized concentration of 0.5%.

4-Chloro-3,5-dimethylphenol Preparation Products And Raw materials

Raw materials

ZINC Xylenol Sulfuryl chloride CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL) 2,4-Dichloro-3,5-dimethylphenol

3,5-Dimethylphenol Chloroform

chevron_left

1of2

chevron_right

Preparation Products

4-Chloro-3,5-dimethylphenol Suppliers

Global( 620)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
N S CHEMICALS AND CONSULTANTS PVT LTD	+91-9867708201 +91-9867708201	Maharashtra, India	18	58	Inquiry
Freesia Chemicals	+9102225689889	Mumbai, India	45	58	Inquiry
Unilab Company	+91-912228260263 +91-63917864522	Tamil Nadu, India	43	58	Inquiry
Mesha Pharma Limited	+91-9320076370 +91-9324291175	Maharashtra, India	24	58	Inquiry
KIP Chemicals Pvt Ltd	+91 8657441706, +91 9167110259	Maharashtra, India	3	58	Inquiry
Super Hygienic Chemicals	+91-9821095252 +91-9821095252	Mumbai, India	23	58	Inquiry
Monachem Specialities LLP	+91-0265-2966227 +91-02652966227	Gujarat, India	35	58	Inquiry
Prasol Chemicals Pvt Ltd	91-22-27782555	Maharashtra, India	27	58	Inquiry
Belchem Industries Private Limited	+91-2224102288 +91-2224102278	Maharashtra, India	17	58	Inquiry
Shiva Pharmachem Pvt Ltd	+91-2652321418 +91-2652321418	Gujarat, India	64	58	Inquiry

Supplier	Advantage
N S CHEMICALS AND CONSULTANTS PVT LTD	58
Freesia Chemicals	58
Unilab Company	58
Mesha Pharma Limited	58
KIP Chemicals Pvt Ltd	58
Super Hygienic Chemicals	58
Monachem Specialities LLP	58
Prasol Chemicals Pvt Ltd	58
Belchem Industries Private Limited	58
Shiva Pharmachem Pvt Ltd	58

4-Chloro-3,5-dimethylphenol Spectrum

4-Chloro-3,5-dimethylphenol(88-04-0)MS 4-Chloro-3,5-dimethylphenol(88-04-0)¹HNMR 4-Chloro-3,5-dimethylphenol(88-04-0)¹³CNMR 4-Chloro-3,5-dimethylphenol(88-04-0)IR1 4-Chloro-3,5-dimethylphenol(88-04-0)IR2 4-Chloro-3,5-dimethylphenol(88-04-0)Raman

88-04-0(4-Chloro-3,5-dimethylphenol)Related Search:

CHLORODIMETHYLVINYLSILANE Xylenol tert-Butyldimethylsilyl chloride 4-Chlorophenol 4-Chloro-3-methylphenol

Chlorodimethylphenylsilane Epichlorohydrin DIMETHYLTHEXYLSILYL CHLORIDE 3,5-Dimethylphenol 3-Chlorophenol

2,5-Dimethylphenol Difluorochloromethane 2,4,6-trichloro-3,5-dimethylphenol 2,4-Dichloro-3,5-dimethylphenol 2,6-DIBROMO-4-CHLORO-3,5-DIMETHYLPHENOL

Chloroacetic acid 2-CHLORO-4,5-DIMETHYLPHENOL,6-Chloro-3,4-dimethylphenol,2-CHLORO-4 5-DIMETHYLPHENOL 99% 4-CHLORO-2,6-DIMETHYLPHENOL

chevron_left

1of4

chevron_right

Dettol, liquid antiseptic Espadol Husept extra huseptextra Nipacide mx Nipacide PX Ottasept Ottasept extra ottaseptextra Parametaxylenol p-Chloro-3,5-xylenol p-chloro-m-xylenol-phenol Phenol, 4-chloro-3,5-dimethyl- Rba 777 rba777 Septiderm-hydrochloride Willenol V Xylenol, 4-chloro- 2-Chloro-m-xylenol 3,5-Xylenol, 4-chloro- 4-CHLORO-META-XYLENOL 4-CHLORO-3,5-XYLENOL 99+% 27) PARA CHLORO META XYLENOL 4-Chloro-3,5-diMethylphenol puruM, >=98.0% (T) Between the chlorine diMethyl phenol 4-Chloro-3.5-d 2,6-DiMethyl-4-hydroxy-1-chlorobenzene 4-Chloro-5,3-diMethylphenol 4 chloro 3,5 diMethylphenol p-Chloro-M-xylenol Chloro-3,5-diMethylp P-Chloro-M-Xylenol (PCMX), 4-Chloro-3,5-diMethylphenol Dett germicide 4-Chloro-3,5-dimethylphenol, 98+% 4-Chloro-3,5-dimethylphenol,99% 4-Chloro-3,5-dimethylphenol,4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol Chloroxylenol (125 mg) 4-Chloro-3,5-dimethy 4-Chloro-3,5-xylenol, 4-Chloro-sym-m-xylenol 4-Chloro-3,5-diMethylphenol, 99% 100GR Ayrtol Benzytol Camel Chloro-3,5-dimethylphenol Chloro-3,5-xylenol Chloro-5-hydroxy-m-xylene Chloro-m-xylenol Chloroxylend Desson BENZYLTOL CHLORO-SYM-XYLENOL 3,5-DIMETHYL-4-CHLORO PHENOL 4-CHLORO-3,5-DIMETHYLPHENOL 4-CHLORO-SYM-M-XYLENOL 4-Chloro-1-hydroxy-3,5-dimethylbenzene 4-chloro-3,5-dimethyl-pheno 4-Chloro-3,5-xylenol GL 4-Chloro-3-xylenol 4-chloro-5-xylenol