4-Chloro-3-methylphenol
- CAS No.
- 59-50-7
- Chemical Name:
- 4-Chloro-3-methylphenol
- Synonyms
- Chlorocresol;PCMC;4-CMC;CMK;PARA CHLORO META CRESOL;4-CHLORO-3-CRESOL;Parmetol;4-CHLORO-M-CRESOL;CMPK;chlorocresols
- CBNumber:
- CB5703115
- Molecular Formula:
- C7H7ClO
- Molecular Weight:
- 142.58
- MOL File:
- 59-50-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/6 17:45:48
| Melting point | 63-65 °C (lit.) |
|---|---|
| Boiling point | 235 °C (lit.) |
| Density | 1.370 |
| vapor pressure | <0.1 hPa (20 °C) |
| refractive index | 1.5449 (estimate) |
| Flash point | 118 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: soluble1g/10 mL, clear, colorless |
| form | Tablets |
| pka | pKa 9.55(t = 25) (Uncertain) |
| color | White |
| PH | 6.5 (1g/l, H2O, 20℃) |
| Water Solubility | 4 g/L (20 ºC) |
| Merck | 14,2133 |
| BRN | 1237629 |
| Henry's Law Constant | 2.5(x 10-6 atm?m3/mol)at 20 °C (calculated, Mabey et al., 1982) |
| Stability | Stable. Incompatible with brass, oxidizing agents, copper, copper alloys. |
| InChIKey | CFKMVGJGLGKFKI-UHFFFAOYSA-N |
| LogP | 3.100 |
| CAS DataBase Reference | 59-50-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 4-chloro-3-methyl-(59-50-7) |
| EPA Substance Registry System | p-Chloro-m-cresol (59-50-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312-H314-H317-H335-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N,T,F | |||||||||
| Risk Statements | 21/22-41-43-50-39/23/24/25-23/24/25-11-38 | |||||||||
| Safety Statements | 26-36/37/39-61-45-36/37-16-7-28 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GO7100000 | |||||||||
| Autoignition Temperature | 590 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29081000 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1830 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
4-Chloro-3-methylphenol price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C55402 | 4-Chloro-3-methylphenol 99% | 59-50-7 | 5G | ₹1753.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C55402 | 4-Chloro-3-methylphenol 99% | 59-50-7 | 100G | ₹2327.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02295 | 4-Chloro-3-methylphenol for synthesis | 59-50-7 | 5G | ₹2460 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C55402 | 4-Chloro-3-methylphenol 99% | 59-50-7 | 500G | ₹3788.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02295 | 4-Chloro-3-methylphenol for synthesis | 59-50-7 | 250G | ₹3580 | 2022-06-14 | Buy |
4-Chloro-3-methylphenol Chemical Properties,Uses,Production
Chemical Properties
white or pink crystals
Physical properties
Colorless, white, or pinkish crystals with a slight phenolic odor. On exposure to air it slowly becomes light brown.
Uses
4-Chloro-3-methylphenol has been used in paint formulations.
Production Methods
Chlorocresol is prepared by the chlorination of m-cresol.
General Description
A pinkish to white crystalline solid with a phenolic odor. Melting point 64-66°C. Shipped as a solid or in a liquid carrier. Soluble in aqueous base. Toxic by ingestion, inhalation or skin absorption. Used as an external germicide. Used as a preservative in paints and inks.
Air & Water Reactions
Hygroscopic. Soluble in aqueous base.
Reactivity Profile
4-Chloro-3-methylphenolS are incompatible with bases, acid chlorides, acid anhydrides, and oxidizing agents. Corrodes steel, brass, copper and copper alloys .
Hazard
Irritant to skin.
Health Hazard
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Pharmaceutical Applications
Chlorocresol is used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It is generally used in concentrations up to 0.2% in a variety of preparations except those intended for oral administration or that contact mucous membrane. Chlorocresol is effective against bacteria, spores, molds, and yeasts; it is most active in acidic media. Preservative efficacy may be reduced in the presence of some other excipients, particularly nonionic surfactants.
Contact allergens
Chlorocresol is a biocide used for its disinfectant and preservative properties, in topicals or cutting fluid.
Safety Profile
Poison by intravenous, subcutaneous, and intraperitoneal routes. Moderately toxic by ingestion. An allergen. Mutation data reported. Incompatible with sodium hydroxide. When heated to decomposition it emits toxic fumes of Cl and phosgene. See also CRESOL and CHLOROPHENOLS.
Potential Exposure
Chlorinated phenol fungicide, microbiocide, and germicide used to control bacteria, yeasts, and fungi.
Environmental Fate
Biological. When p-chloro-m-cresol was statically incubated in the dark at 25 °C with yeast
extract and settled domestic wastewater inoculum, significant biodegradation with rapid
adaptation was observed. At concentrations of 5 and 10 mg/L, 78 and 76% biodegradation,
respectively, were observed after 7 d (Tabak et al., 1981).
Chemical/Physical. At influent concentrations (pH 3.0) of 1.0, 0.1, 0.01, and 0.001 mg/L, the
GAC adsorption capacities were 122, 63, 32, and 17 mg/g, respectively. At pH 5.5 and pH 9.0 at
influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 124,
85, 58, and 40 mg/g and 99, 38, 15, and 5.5 mg/g, respectively (Dobbs and Cohen, 1980).
storage
Chlorocresol is stable at room temperature but is volatile in steam. Aqueous solutions may be sterilized by autoclaving. On exposure to air and light, aqueous solutions may become yellow colored. Solutions in oil or glycerin may be sterilized by heating at 1608℃ for 1 hour. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
Shipping
UN2669 Chlorocresols solution, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3437 Chlorocresols solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise the phenol from pet ether or *C6H6. [Beilstein 6 H 381, 6 I 187, 6 II 355, 6 III 1315, 6 IV 2064.]
Incompatibilities
Chlorocresols react with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Contact with oxidizing agents may cause a fire and explosion hazard. Heat produces phosgene, hydrogen chloride and chlorine gases. Corrosive to aluminum, copper, tin, and other chemically active metals.
Waste Disposal
A good candidate for rotary kiln incineration at a temperature range of 820 to 1600C and residence times of seconds for liquids and gases, and hours for solids.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical creams
and emulsions). Included in nonparenteral and parenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients.
In Europe, chlorocresol is approved for use in cosmetics at a
maximum concentration of 0.2%; however, it is prohibited for use
in products intended to come into contact with mucous membranes.
In Japan, use of chlorocresol in cosmetics is restricted to a level of
0.5 g/100 g.
4-Chloro-3-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
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| Bridge Chem PrivateLimited | +91-22-6661 1488 | Mumbai, India | 15 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| VAV Life Sciences Pvt. Ltd. | 91-22-22836802 | Maharashtra, India | 12 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| N S CHEMICALS AND CONSULTANTS PVT LTD | 58 |
| Freesia Chemicals | 58 |
| JSK Chemicals | 58 |
| Super Hygienic Chemicals | 58 |
| P C Chem | 58 |
| U.P. Chemicals | 58 |
| Bridge Chem PrivateLimited | 58 |
| HiMedia Laboratories | 58 |
| VAV Life Sciences Pvt. Ltd. | 58 |
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