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Difluoroacetic acid

Difluoroacetic acid Structure
CAS No.
381-73-7
Chemical Name:
Difluoroacetic acid
Synonyms
2,2-DIFLUOROACETIC ACID;DIFLUOROACETATE;ifluoroaceticaci;VITAS-BB TBB000649;difluoro-aceticaci;DIFLUOROACETIC ACID;Difluoroaceticacid98%;Acetic acid, difluoro-;1,1-DIFLUOROACETIC ACID;Twotrifluoroacetic acid
CBNumber:
CB2700577
Molecular Formula:
C2H2F2O2
Molecular Weight:
96.03
MOL File:
381-73-7.mol
MSDS File:
SDS
Modify Date:
2023/11/8 17:00:29

Difluoroacetic acid Properties

Melting point -1 °C (lit.)
Boiling point 132-134 °C (lit.)
Density 1.526 g/mL at 25 °C (lit.)
vapor pressure 11.7hPa at 25℃
refractive index n20/D 1.344(lit.)
Flash point 174 °F
storage temp. 2-8°C
solubility 540.54g/L in organic solvents at 20 ℃
form Liquid
pka pK1:1.33 (25°C)
Specific Gravity 1.527 (20℃)
color Clear colorless to light brown
Water Solubility 1000g/L at 37℃
BRN 1098588
InChIKey PBWZKZYHONABLN-UHFFFAOYSA-N
LogP 0.601 at 37℃
CAS DataBase Reference 381-73-7(CAS DataBase Reference)
NIST Chemistry Reference Difluoroacetic acid(381-73-7)
EPA Substance Registry System Acetic acid, difluoro- (381-73-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H412
Precautionary statements  P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C
Risk Statements  34-35
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  AG9900000
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29159080
NFPA 704
2
3 0

Difluoroacetic acid price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 142859 Difluoroacetic acid 98% 381-73-7 5G ₹4546.5 2022-06-14 Buy
Sigma-Aldrich(India) 00922 Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC) 381-73-7 1ML ₹4200.1 2022-06-14 Buy
Sigma-Aldrich(India) 142859 Difluoroacetic acid 98% 381-73-7 25G ₹17460.73 2022-06-14 Buy
Sigma-Aldrich(India) 00922 Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC) 381-73-7 10X1ML ₹25893.4 2022-06-14 Buy
Sigma-Aldrich(India) 00922 Difluoroacetic acid for LC-MS LiChropur?, ≥97.5% (GC) 381-73-7 50ML ₹82399.9 2022-06-14 Buy
Product number Packaging Price Buy
142859 5G ₹4546.5 Buy
00922 1ML ₹4200.1 Buy
142859 25G ₹17460.73 Buy
00922 10X1ML ₹25893.4 Buy
00922 50ML ₹82399.9 Buy

Difluoroacetic acid Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light brown liquid

Uses

Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

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1,1-DIFLUOROACETIC ACID VITAS-BB TBB000649 DIFLUOROACETIC ACID Acetic acid, difluoro- difluoro-aceticaci Difluoroaceticacid98% Difluoroacetic acid, 98% 10ML Difluoroacetic acid, 98% 2.5ML 2,2-Difluoroethanoic acid Twotrifluoroacetic acid Aceticacid, 2,2-difluoro- Difluoroacetic acid, 97%+ Difluoroacetic Acid > ifluoroaceticaci DIFLUOROACETATE 2,2-DIFLUOROACETIC ACID 381-73-7 7381-73-7 F2CHCO2H F2CHCOOH CHF2COOH C2H2F2O2 CARBOXYLIC ACID Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Fluorinated Building Blocks Synthetic Reagents Organic Acids Pharmaceutical Intermediates Small molecule Organic Fluorides Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Synthetic Organic Chemistry Chemical Synthesis Organic Acids Synthetic Reagents