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Davercin

Davercin Structure
CAS No.
55224-05-0
Chemical Name:
Davercin
Synonyms
erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Davercin, 10 mM in DMSO;Eritromicina A carbonato;Erythromycin Impurity 10;Erythromycin Impurity 50
CBNumber:
CB2966540
Molecular Formula:
C38H65NO14
Molecular Weight:
759.93
MOL File:
55224-05-0.mol
MSDS File:
SDS
Modify Date:
2025/4/30 15:13:52
Request For Quotation

Davercin Properties

Melting point >135°C (dec.)
Boiling point 859.8±65.0 °C(Predicted)
Density 1.22±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka 13.49±0.70(Predicted)
form Solid
color White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Toxicity LD50 oral in rat: 5800mg/kg

Davercin Chemical Properties,Uses,Production

Description

Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

Uses

Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Davercin Preparation Products And Raw materials

Raw materials

Preparation Products

Davercin Suppliers

Global( 141)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29855 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-29-87569262 +86-15003564040 China 3293 58 Inquiry
TargetMol Chemicals Inc. +17819995354 United States 32297 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 7922 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
Shaanxi Dideu Medichem Co. Ltd 58
TargetMol Chemicals Inc. 58
Shaanxi Dideu Medichem Co. Ltd 58

55224-05-0(Davercin)Related Search:

Erythromycin 3-Dimethylaminopropylamine CYCLANDELATE CHLOROPHOSPHONAZO III Dimethyl carbonate
Ethylene carbonate Lithium carbonate Calcium carbonate Sodium carbonate Roxithromycin
CYCLOPENTOLATE Erythromycin Impurity 9 DIBUTYL CARBONATE 4-ETHYL-1,3-DIOXOLAN-2-ONE (S)-(-)-Propylene Carbonate
(R)-(+)-Propylene carbonate 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE (R)-(+)-4-(METHOXYMETHYL)-1,3-DIOXOLAN-2-ONE
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Erythromycin Cyclocarbonate DAVERCIN CWE (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione Carbonato ciclico de eritromicina a Carbonato ciclico de eritromicina A [spanish] Cykliczny weglan erytromycyny a Cykliczny weglan erytromycyny A [polish] Dravercin Eritromicina A carbonato Eritromicina A carbonato [spanish] ErythroMycin A 11,12-carbonate, ErythroMycin A cyclic 11,12-carbonate, ErythroMycin cyclic carbonate Cyclic ester of erythroMycin cyclic 11,12-carbonate erythromycin Erythromycin Impurity 10 Erythromycin Cyclocarbonate, >98% Erythromycin, cyclic 11,12-carbonate Erythromycin Impurity 20（Erythromycin Cyclocarbonate） Davercin USP/EP/BP Erythromycin Cyclic11,12-Carbonate(Davercin) Erythromycin Impurity 50 (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-hydroxy-8-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3a,7,9,11,13,15-hexamethyloctahy Davercin (Erythromycin cyclocarbonate) erythromycin A cyclic 11,12-carbonate Erythromycin cycloester Erythromycin cyclic carbonate Erythromycin Impurity 10(Davercin) Davercin, 10 mM in DMSO Erythromycin cyclocarbonate (Davercin) 55224-05-0 C38H65NO14 Inhibitors 55224-05-0