Davercin

CAS No.: 55224-05-0

Chemical Name:: Davercin

Synonyms: erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Eritromicina A carbonato;Erythromycin Impurity 10;Erythromycin Impurity 50;Erythromycin Cyclocarbonate

CBNumber:: CB2966540

Molecular Formula:: C38H65NO14

Molecular Weight:: 759.93

MOL File:: 55224-05-0.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 9:03:09

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Davercin Properties

Melting point	>135°C (dec.)
Boiling point	859.8±65.0 °C(Predicted)
Density	1.22±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	13.49±0.70(Predicted)
form	Solid
color	White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Toxicity	LD50 oral in rat: 5800mg/kg

Davercin Chemical Properties,Uses,Production

Description

Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD₅₀s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

Uses

Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Davercin Preparation Products And Raw materials

Raw materials

Preparation Products

Davercin Suppliers

Global( 113)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	China	2132	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

55224-05-0(Davercin)Related Search:

Erythromycin 3-Dimethylaminopropylamine CYCLANDELATE CHLOROPHOSPHONAZO III Dimethyl carbonate

Ethylene carbonate Lithium carbonate Calcium carbonate Sodium carbonate Roxithromycin

CYCLOPENTOLATE Erythromycin Impurity 9 DIBUTYL CARBONATE 4-ETHYL-1,3-DIOXOLAN-2-ONE (S)-(-)-Propylene Carbonate

(R)-(+)-Propylene carbonate 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE (R)-(+)-4-(METHOXYMETHYL)-1,3-DIOXOLAN-2-ONE

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Erythromycin Cyclocarbonate DAVERCIN CWE (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione Carbonato ciclico de eritromicina a Carbonato ciclico de eritromicina A [spanish] Cykliczny weglan erytromycyny a Cykliczny weglan erytromycyny A [polish] Dravercin Eritromicina A carbonato Eritromicina A carbonato [spanish] ErythroMycin A 11,12-carbonate, ErythroMycin A cyclic 11,12-carbonate, ErythroMycin cyclic carbonate Cyclic ester of erythroMycin cyclic 11,12-carbonate erythromycin Erythromycin Impurity 10 Erythromycin Cyclocarbonate, >98% Erythromycin, cyclic 11,12-carbonate Erythromycin Impurity 20（Erythromycin Cyclocarbonate） Davercin USP/EP/BP Erythromycin Cyclic11,12-Carbonate(Davercin) Erythromycin Impurity 50 (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-hydroxy-8-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3a,7,9,11,13,15-hexamethyloctahy Davercin (Erythromycin cyclocarbonate) erythromycin A cyclic 11,12-carbonate Erythromycin cycloester Erythromycin Impurity 10(Davercin) 55224-05-0 C38H65NO14 Inhibitors 55224-05-0