VitaMin D4
- CAS No.
- 511-28-4
- Chemical Name:
- VitaMin D4
- Synonyms
- VITAMIN D;COLECALCIFEROL;CALCIOL;RACUMIN D;Duphafral;Vtamin D4;vitamin D4;VITAMINE D4;OLEOVITAMIN D3;CHOLECALCIFEROLUM
- CBNumber:
- CB3104866
- Molecular Formula:
- C28H46O
- Molecular Weight:
- 398.66
- MOL File:
- 511-28-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 83-86 °C(lit.) |
|---|---|
| alpha | D18 +89.3° (c = 0.47 in acetone) |
| Boiling point | 504.9±29.0 °C(Predicted) |
| Density | 0.96 |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform |
| form | Powder |
| pka | 14.74±0.20(Predicted) |
| color | Off-white to light yellow |
| Stability | Hygroscopic, Temperature Sensitive |
| CAS DataBase Reference | 511-28-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311-H330-H372 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 24/25-26-48/25 | |||||||||
| Safety Statements | 28-36/37 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | VS2900000 | |||||||||
| F | 8-10-23 | |||||||||
| NFPA 704 |
|
VitaMin D4 Chemical Properties,Uses,Production
Description
Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.
Chemical Properties
Pale Yellow Oil
Uses
Vitamin D4 is the active analogue of Vitamin D.
Biological Functions
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.
VitaMin D4 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5866 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |