ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic acids >5-Chloro-2-thiophenecarboxylic Acid
5-Chloro-2-thiophenecarboxylic Acid
- CAS No.
- 24065-33-6
- Chemical Name:
- 5-Chloro-2-thiophenecarboxylic Acid
- Synonyms
- 5-Chlorothiophene-2-carboxylic;5-chloro-2-thiophenecarboxylicaci;5-Chlorothiophen-2-carboxylic acid;5-CHLORO-2-THIOPHENECARBOXYLIC ACID;NSC 14776;AKOS B000092;Rivaroxaban F;2-Amino-9-picoline;RARECHEM AL BE 0303;TIMTEC-BB SBB003937
- CBNumber:
- CB3189269
- Molecular Formula:
- C5H3ClO2S
- Molecular Weight:
- 162.59
- MOL File:
- 24065-33-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 154-158 °C(lit.) |
|---|---|
| Boiling point | 287.0±20.0 °C(Predicted) |
| Density | 1.466 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.32±0.10(Predicted) |
| form | Powder |
| color | Cream-yellow |
| BRN | 118361 |
| InChI | InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8) |
| InChIKey | QZLSBOVWPHXCLT-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)SC(Cl)=CC=1 |
| CAS DataBase Reference | 24065-33-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Chloro-2-thiophenecarboxylic acid(24065-33-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H319 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-43-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XM8400000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
5-Chloro-2-thiophenecarboxylic Acid price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 633003 | 5-Chlorothiophene-2-carboxylic acid 97% | 24065-33-6 | 5G | ₹2944.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 633003 | 5-Chlorothiophene-2-carboxylic acid 97% | 24065-33-6 | 5G | ₹2944.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 633003 | 5-Chlorothiophene-2-carboxylic acid 97% | 24065-33-6 | 25G | ₹6603.25 | 2022-06-14 | Buy |
| ALFA India | ALF-A15209-22 | 5-Chlorothiophene-2-carboxylic acid, 98% | 24065-33-6 | 100g | ₹26099 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C1230 | 5-Chlorothiophene-2-carboxylic Acid min. 95.0 % | 24065-33-6 | 5G | ₹3300 | 2022-05-26 | Buy |
5-Chloro-2-thiophenecarboxylic Acid Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powder
Uses
5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:
- rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
- 5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones
Synthesis
The compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed.
1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.
5-Chloro-2-thiophenecarboxylic Acid Preparation Products And Raw materials
Raw materials
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| BTC pharm India | 58 |
| GLR Innovations | 58 |
| EPOCH LABS | 58 |
| Synocule research labs private limited | 58 |
| PURALABS | 58 |
| ANJI BIOSCIENCES | 58 |
| Vijayasai Lifesciences | 58 |
| SURVIVAL TECHNOLOGIES LIMITED | 58 |
| TRC FINE CHEMS | 58 |
| SPC LIFESCIENCES PVT. LTD | 58 |
24065-33-6(5-Chloro-2-thiophenecarboxylic Acid)Related Search:
Rivaroxaban Impurity 43
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
2-Thiophenecarboxylic acid
(S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
Rivaroxaban Impurity 41
(S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid
(S)-(+)-Glycidyl Phthalimide
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5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
AKOS B000092
2-Thiophenecarboxylic acid, 5-chloro-
Chlorothiophene-2-carboxy
5-Chlorothiophene-2-carboxylic Acid, 97+%
Rivaroxaban Impurity 40
TIMTEC-BB SBB003937
RARECHEM AL BE 0303
5-Chlorothiophene-2-carboxylicacid,98%
2-CHLOROTHIOPHENE-5-FORMIC ACID
CHLOROTHIOPHENEDICARBOXYLICACID
5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 98%
5- Chlorothiophene-2-carboxilic acid
5-chlorothiophene-2-carboxylic acid(SALTDATA: FREE)
Rivaroxaban Intermediate 4
2-Chloro-5-carboxythiophene
NSC 14776
ethyl 4-(3-oxoMorpholino) phenylcarbaMate
Rivaroxaban Impurity N
Rivaroxaban CTCA Impurity
Rivaroxaban F
orothiophene-2-carboxyL
5-Chlorothiophene-2-carboxylicAcid>
Rivaroxaban EP Impurity F
Rivaroxaban intermediates，5-Chloro-2-thiophenecarboxylic acid
5-Chlorothiophene-2-Carboxylic Acide
5-Chlorothiophene-2-carboxylic acid (Rivaroxaban impurity)
Rivaroxaban Impurity C/ Rivaroxaban CTCA Impurity
Rivaroxaban EP Impurity F/Rivaroxaban CTCA Impurity
Rivaroxaban Intermediates 5-Chlorothiophene-2-Carboxylic Acid 24065-33-6
2-Amino-9-picoline
5-Chloro-2-carboxylic acid
5-chlorothiophene-2-carboxylic acidc
5-CHLORO-2-THIOPHENECARBOXYLIC ACID
5-chloro-2-thiophenecarboxylicaci
5-Chlorothiophene-2-carboxylic
5-Chlorothiophen-2-carboxylic acid
5-Chlorothiophene-2-Carboxylic acid (CTA)
5-Chloro Thiophene-2-Carboxylic Acid (5-CTC)
5-ChloroThiophene-2-Carboxylic acid [5CTA]
24065-33-6
24069-33-6
C5H2ClO2S
Building Blocks
Thiophenes
Halogenated Heterocycles
Heterocyclic Building Blocks
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals
Sulfur & Selenium Compounds
Intermediates
Thiophene&Benzothiophene
Miscellaneous
Halogenated Heterocycles
Heterocyclic Building Blocks
Thiophenes
ThiophenesBuilding Blocks