beta-Hydroxyisovaleric Acid
- CAS No.
- 625-08-1
- Chemical Name:
- beta-Hydroxyisovaleric Acid
- Synonyms
- 3-Hydroxyisovaleric acid;3-HYDROXY-3-METHYLBUTANOIC ACID;3-HYDROXY-3-METHYL BUTYRIC ACID;β-Hydroxyisovaleric Acid;BETA-HYDROXY BETA-METHYLBUTYRATE;RARECHEM AL BO 2324;3-OH-isovaleric acid;HYDROXY-METHYLBUTYRATE;3-hydroxyisovalericaci;?Hydroxyisovaleric acid
- CBNumber:
- CB3213104
- Molecular Formula:
- C5H10O3
- Molecular Weight:
- 118.13
- MOL File:
- 625-08-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | ?80 °C (lit.) |
|---|---|
| Boiling point | 88 °C/1 mmHg (lit.) |
| Density | 0.938 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 113 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility |
DMF:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) DMSO:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);84.65(Max Conc. mM) |
| pka | 4.38±0.10(Predicted) |
| form | Liquid |
| Specific Gravity | 1.10 |
| color | Pale yellow |
| Water Solubility | Soluble in water and ethanol. |
| BRN | 1743952 |
| InChIKey | AXFYFNCPONWUHW-UHFFFAOYSA-N |
| CAS DataBase Reference | 625-08-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3334 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-13-21 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
beta-Hydroxyisovaleric Acid price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 55453 | β-Hydroxyisovaleric acid ≥95.0% (T) | 625-08-1 | 1G | ₹28935.23 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0701 | β-Hydroxyisovaleric Acid min. 96.0 % | 625-08-1 | 5G | ₹6900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H0701 | β-Hydroxyisovaleric Acid min. 96.0 % | 625-08-1 | 25G | ₹19800 | 2022-05-26 | Buy |
beta-Hydroxyisovaleric Acid Chemical Properties,Uses,Production
Description
β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following:
Increased sarcolemmal integrity via conversion to HMG-CoA
Enhanced protein synthesis via the mTOR pathway
Depression of protein degradation through inhibition of the ubiquitin pathway
Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries.
The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.
Chemical Properties
colorless to light yellow liquid
Uses
β-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.
Definition
ChEBI: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
beta-Hydroxyisovaleric Acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | China | 8808 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12806 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5868 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3692 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29730 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19841 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
Related articles
- What is Beta-Hydroxy-Beta-Methylbutyrate?
- Beta-hydroxy-beta-methylbutyrate is a leucine metabolite that is generally utilized to promote muscle-building and increase ph....
- Oct 24，2019
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