ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Glutamic acid derivatives >3-HYDROXY-3-METHYLGLUTARIC ACID

3-HYDROXY-3-METHYLGLUTARIC ACID

CAS No.: 503-49-1

Chemical Name:: 3-HYDROXY-3-METHYLGLUTARIC ACID

Synonyms: Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1

CBNumber:: CB1454369

Molecular Formula:: C6H10O5

Molecular Weight:: 162.14

MOL File:: 503-49-1.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 15:51:00

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3-HYDROXY-3-METHYLGLUTARIC ACID Properties

Melting point	105-108 °C (lit.)
Boiling point	120 °C / 13mmHg
Density	1.2132 (rough estimate)
refractive index	1.4230 (estimate)
storage temp.	-20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
form	powder to crystal
pka	3.95±0.10(Predicted)
color	White to Light yellow
Merck	14,5808
BRN	1769194
CAS DataBase Reference	503-49-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

MA3753000

HS Code

29181990

Toxicity

LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)

NFPA 704

	0
2		0

3-HYDROXY-3-METHYLGLUTARIC ACID price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H4392	3-Hydroxy-3-methylglutaric acid ≥95%	503-49-1	100MG	₹9255.38	2022-06-14	Buy
Sigma-Aldrich(India)	H4392	3-Hydroxy-3-methylglutaric acid ≥95%	503-49-1	1G	₹51667.73	2022-06-14	Buy
Sigma-Aldrich(India)	91387	3-Hydroxy-3-methylglutaric acid analytical standard	503-49-1	10MG	₹5877.98	2022-06-14	Buy
Sigma-Aldrich(India)	91387	3-Hydroxy-3-methylglutaric acid analytical standard	503-49-1	50MG	₹11896.68	2022-06-14	Buy
TCI Chemicals (India)	H0436	3-Hydroxy-3-methylglutaric Acid min. 90.0 %	503-49-1	100MG	₹17800	2022-05-26	Buy

Product number	Packaging	Price	Buy
H4392	100MG	₹9255.38	Buy
H4392	1G	₹51667.73	Buy
91387	10MG	₹5877.98	Buy
91387	50MG	₹11896.68	Buy
H0436	100MG	₹17800	Buy

3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Uses,Production

Description

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemical Properties

White Solid

Uses

antihyperlipoproteinemia

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

Purification Methods

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials

Raw materials

Potassium hydroxide Hydrogen peroxide Sodium sulfate Tetrahydrofuran Diethyl ether

Ethyl acetate Dichloromethane Allyl bromide Acetic acid Magnesium

Sulfuric acid

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Preparation Products

3-METHYLPENTANE-1,3,5-TRIOL D(+)-Glucose 3-ACETOXY-3-METHYLPENTANE-1,5-DIOIC ACID ANHYDRIDE

3-HYDROXY-3-METHYLGLUTARIC ACID Suppliers

Global( 117)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Eburon Organics (I) Pvt, Ltd	+91 260 240 0894	Gujarat, India	114	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3777	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29825	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8618339805032	China	13183	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
Eburon Organics (I) Pvt, Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Henan Alfa Chemical Co., Ltd	58

3-HYDROXY-3-METHYLGLUTARIC ACID Spectrum

3-HYDROXY-3-METHYLGLUTARIC ACID(503-49-1)MS 3-HYDROXY-3-METHYLGLUTARIC ACID(503-49-1)¹HNMR 3-HYDROXY-3-METHYLGLUTARIC ACID(503-49-1)IR1 3-HYDROXY-3-METHYLGLUTARIC ACID(503-49-1)IR2

503-49-1(3-HYDROXY-3-METHYLGLUTARIC ACID)Related Search:

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SODIUM DIHYDROGEN CITRATE Sodium citrate 3-HYDROXY-3-METHYLGLUTARIC ACID Triethyl citrate Alverine citrate

1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt Acetyl tributyl citrate oxeladin Ammonium ferric citrate Trimagnesium dicitrate

TRIMETHYL CITRATE AMMONIUM BISMUTH CITRATE FERRIC CITRATE

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