3-HYDROXY-3-METHYLGLUTARIC ACID
![3-HYDROXY-3-METHYLGLUTARIC ACID Structure](CAS/GIF/503-49-1.gif)
- CAS No.
- 503-49-1
- Chemical Name:
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- Synonyms
- Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
- CBNumber:
- CB1454369
- Molecular Formula:
- C6H10O5
- Molecular Weight:
- 162.14
- MOL File:
- 503-49-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 15:51:00
Melting point | 105-108 °C (lit.) |
---|---|
Boiling point | 120 °C / 13mmHg |
Density | 1.2132 (rough estimate) |
refractive index | 1.4230 (estimate) |
storage temp. | -20°C |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml |
form | powder to crystal |
pka | 3.95±0.10(Predicted) |
color | White to Light yellow |
Merck | 14,5808 |
BRN | 1769194 |
CAS DataBase Reference | 503-49-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 22-24/25-36-26 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | MA3753000 | |||||||||
F | 10 | |||||||||
HS Code | 29181990 | |||||||||
Toxicity | LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien) | |||||||||
NFPA 704 |
|
3-HYDROXY-3-METHYLGLUTARIC ACID price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H4392 | 3-Hydroxy-3-methylglutaric acid ≥95% | 503-49-1 | 100MG | ₹9255.38 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H4392 | 3-Hydroxy-3-methylglutaric acid ≥95% | 503-49-1 | 1G | ₹51667.73 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 91387 | 3-Hydroxy-3-methylglutaric acid analytical standard | 503-49-1 | 10MG | ₹5877.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 91387 | 3-Hydroxy-3-methylglutaric acid analytical standard | 503-49-1 | 50MG | ₹11896.68 | 2022-06-14 | Buy |
TCI Chemicals (India) | H0436 | 3-Hydroxy-3-methylglutaric Acid min. 90.0 % | 503-49-1 | 100MG | ₹17800 | 2022-05-26 | Buy |
3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Uses,Production
Description
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
Chemical Properties
White Solid
Uses
antihyperlipoproteinemia
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Eburon Organics (I) Pvt, Ltd | +91 260 240 0894 | Gujarat, India | 114 | 58 | Inquiry |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13183 | 58 | Inquiry |
503-49-1(3-HYDROXY-3-METHYLGLUTARIC ACID)Related Search:
1of4
chevron_right