Nadifloxacin
- CAS No.
- 124858-35-1
- Chemical Name:
- Nadifloxacin
- Synonyms
- NDFX;Acuati;Acuatim;opc7251;Nadiflo;Nafloxacin;Nadiroxisan;Jinofloxacin;NADIFLOXACIN;Nadifiloxacin
- CBNumber:
- CB3301560
- Molecular Formula:
- C19H21FN2O4
- Molecular Weight:
- 360.38
- MOL File:
- 124858-35-1.mol
- Modify Date:
- 2023/11/3 14:46:39
Melting point | 245-2470C (dec) |
---|---|
Boiling point | 624.9±55.0 °C(Predicted) |
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Sparingly, Heated) |
form | White to yellow crystalline solid. |
pka | 5.55±0.40(Predicted) |
color | White to Off-White |
Merck | 14,6345 |
InChI | InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26) |
InChIKey | JYJTVFIEFKZWCJ-UHFFFAOYSA-N |
SMILES | C12=CC(F)=C(N3CCC(O)CC3)C3=C1N(C(C)CC3)C=C(C(O)=O)C2=O |
CAS DataBase Reference | 124858-35-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2933.99.7500 |
Toxicity | LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto) |
Nadifloxacin price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SMB00375 | Nadifloxacin ≥98% (HPLC) | 124858-35-1 | 100MG | ₹5585.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SMB00375 | Nadifloxacin ≥98% (HPLC) | 124858-35-1 | 1G | ₹31825.5 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | CDS021591 | Nadifloxacin | 124858-35-1 | 25MG | ₹6170.25 | 2022-06-14 | Buy |
TCI Chemicals (India) | N0931 | Nadifloxacin | 124858-35-1 | 200MG | ₹3900 | 2022-05-26 | Buy |
TCI Chemicals (India) | N0931 | Nadifloxacin | 124858-35-1 | 1G | ₹10400 | 2022-05-26 | Buy |
Nadifloxacin Chemical Properties,Uses,Production
Description
Nadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria and against anaerobic bacteria. It produces significant improvement in patients with Propionibacterium acnes infection and does not appear to cause cross-resistance to other antibiotic agents. Its potent antimicrobial activity has also been demonstrated in the Pseudomonas aeruginosa burn wound infection model in mice. Nadifloxacin exerts its antibiotic activity by inhibiting the formation of supercoiled DNA by DNA gyrase.
Chemical Properties
Off-White Crystalline Solid
Uses
Nadifloxacin is a topical fluorinated quinolone antibacterial used to treat skin conditions such as acne and other dermal infections caused by bacteria. This drug belongs to a class of calcium salt of polyacrylic acid crosslinked with divinyl glycol with minimal AEs.
Definition
ChEBI: Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.
Pharmaceutical Applications
A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.
Nadifloxacin Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
JR Corporation | +91-9099076719 +91-7096568000 | Gujarat, India | 14 | 58 | Inquiry |
Turtle Pharma Private Limited | +91-9850998504 +91-9850998504 | Maharashtra, India | 27 | 58 | Inquiry |
Lewens Labs | +917043057100 | Gujarat, India | 30 | 58 | Inquiry |
Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
KPS Chemicals & Pharmaceuticals | 91--8469484608 | Gujarat, India | 240 | 58 | Inquiry |
Globofarm International Private Limited | 91-22-49716506 | Maharashtra, India | 188 | 58 | Inquiry |
Matrix Pharma | 91-22-28606131 | Maharashtra, India | 28 | 58 | Inquiry |
Sneha Medicare Pvt. Ltd. | 91-22-25006901 | Maharashtra, India | 60 | 58 | Inquiry |
Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Hetero Drugs Limited | 58 |
JR Corporation | 58 |
Turtle Pharma Private Limited | 58 |
Lewens Labs | 58 |
Clearsynth Labs | 58 |
KPS Chemicals & Pharmaceuticals | 58 |
Globofarm International Private Limited | 58 |
Matrix Pharma | 58 |
Sneha Medicare Pvt. Ltd. | 58 |
Innovative Synthetic Molecules | 58 |
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