2'-Fluoro-2'-deoxyuridine
- CAS No.
- 784-71-4
- Chemical Name:
- 2'-Fluoro-2'-deoxyuridine
- Synonyms
- 2'-FU;2-FdU;2'-FUDR;2'-F-2'-dU;Fioluridine;2'-FLUORO-D-URIDINE;2'-Fluoro-2'-deoxyur;2'-F-2'-deoxyuridine;2'-F-2'-deoxyuridine;2 '- Fluorodeoxyuridine
- CBNumber:
- CB3358175
- Molecular Formula:
- C9H11FN2O5
- Molecular Weight:
- 246.19
- MOL File:
- 784-71-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/12 8:58:12
| Melting point | 147.0 to 153.0 °C |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| refractive index | 53 ° (C=0.3, H2O) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in methanol. |
| form | Powder |
| pka | 9.39±0.10(Predicted) |
| color | White to Off-white |
| optical activity | α20/D +53°±3°, c = 0.3 in water |
| Water Solubility | soluble in water |
| InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O |
| CAS DataBase Reference | 784-71-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H341b |
| Precautionary statements | P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-40 |
| Safety Statements | 22-36/37/39 |
| HS Code | 29389090 |
2'-Fluoro-2'-deoxyuridine price More Price(2)
2'-Fluoro-2'-deoxyuridine Chemical Properties,Uses,Production
Chemical Properties
White to almost white crystalline powder
Uses
2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Synthesis
Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.
2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1262 | 58 | Inquiry |
| APAC Sourcing Solutions Ltd. | 91-124-4007103 | Haryana, India | 61 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| Oceanic Pharmachem Pvt. Ltd. | 91-22-42128600 | Maharashtra, India | 2005 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4217 | 58 | Inquiry |
| ChemExpress | +86-021-58950125 +86-021-58950125; | China | 737 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12840 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | China | 5857 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| APAC Sourcing Solutions Ltd. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Manus Aktteva | 34 |
| Oceanic Pharmachem Pvt. Ltd. | 58 |
| Reax Chemicals | 58 |
| ChemExpress | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
| Hebei Yanxi Chemical Co., Ltd. | 58 |
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