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2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide Structure
CAS No.
322-35-0
Chemical Name:
2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide
Synonyms
BENSERAZIDE;Serazide;BENSERASZIDE;BenserazideBase;Levodopa Impurity 8;evodopa and Benserazide;dl-seryltrihydroxybenzylhydrazine;evodopa and Benserazide USP/EP/BP;2-(2,3,4-trihydroxybenzyl)hyrazide,dl-serin;Benserazide Hydrochloride 14919-77-8 / Base:
CBNumber:
CB3384419
Molecular Formula:
C10H15N3O5
Molecular Weight:
257.24
MOL File:
322-35-0.mol
Modify Date:
2022/12/21 16:56:50

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide Properties

Boiling point 574.2±50.0 °C(Predicted)
Density 1.541±0.06 g/cm3(Predicted)
pka 9.40±0.40(Predicted)
CAS DataBase Reference 322-35-0(CAS DataBase Reference)

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide Chemical Properties,Uses,Production

Uses

Inhibitor (decarboxylase).

Definition

ChEBI: A carbohydrazide that results from the formal condensation of the carboxy group of DL-serine with the primary amino group of 4-(hydrazinylmethyl)benzene-1,2,3-triol. An aromatic-L-amino-acid decarboxylase nhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, t causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide has no antiparkinson actions when given alone.

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propionohydrazide 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide 2-azanyl-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide Benserazide analogue: 1-(2,3,4-trihydroxybenzyl)-2-Methylhydrazine Benserazide Metabolite: 2,3,4-trihydroxybenzylhydrazine 2-aMino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide 2-(2,3,4-trihydroxybenzyl)hyrazide,dl-serin dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide dl-seryltrihydroxybenzylhydrazine BENSERASZIDE BenserazideBase Benserazide Hydrochloride 14919-77-8 / Base: DL-Serine 2-[2,3,4-trihydroxybenzyl] hydrazide N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine N1-(DL-Seryl)-N2-(2,3,4-trihydroxybenzyl)hydrazine Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide (7CI) Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, DL- (8CI) Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide 2-amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide evodopa and Benserazide Levodopa Impurity 8 evodopa and Benserazide USP/EP/BP 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide USP/EP/BP BENSERAZIDE Serazide 322-35-0 C10H16ClN3O3 Benserazide