Daltroban
- CAS No.
- 79094-20-5
- Chemical Name:
- Daltroban
- Synonyms
- BM-13505;DALTROBAN;SKF-96148;Daltroban USP/EP/BP;DatelliptiumChloride;Daltroban >98% (HPLC);4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid;4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID;2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid;4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
- CBNumber:
- CB3384707
- Molecular Formula:
- C16H16ClNO4S
- Molecular Weight:
- 353.82
- MOL File:
- 79094-20-5.mol
- Modify Date:
- 2024/5/8 11:20:22
| Melting point | 132.5-137.4 °C(lit.) |
|---|---|
| Boiling point | 555.3±60.0 °C(Predicted) |
| Density | 1.378±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 22 mg/mL, soluble |
| form | A solid |
| pka | 4.33±0.10(Predicted) |
| color | white |
| InChI | InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20) |
| InChIKey | IULOBWFWYDMECP-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=C(CCNS(C2=CC=C(Cl)C=C2)(=O)=O)C=C1 |
| CAS DataBase Reference | 79094-20-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Daltroban Chemical Properties,Uses,Production
Description
Daltroban (BM 13505, SKF 96148), a specific thromboxane A2 receptor antagonist, was studied as an antithrombotic agent. Daltroban increases intracellular calcium in vascular smooth muscle cells. Daltroban shows a protective effect in reperfusion injury. The drug was licensed to Smith Kline Beecham and underwent phase III clinical trials in the UK and Germany as an antithrombotic agent but did not enter clinical trials in the USA. Besides, вaltroban was investigated in patients with an ischemic heart disorder. However, the development of daltroban has been discontinued.
Uses
Daltroban can be used as a2 receptor to target adipose-derived stem cell for treating ischemic diseases.
Uses
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist that increases intracellular calcium ions in vascular smooth muscle cells and protects against reperfusion injury after myocardial ischaemia but not in coronary artery endothelial cells. Daltroban may also be useful in the treatment of patients with COPD-related pulmonary hypertension.
target
TXA2
Daltroban Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Daltroban Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| Finetech Industry Limited | 027-87465837 19945049750 | China | 9649 | 58 | Inquiry |
| MedChemExpress | 021-58955995 | United States | 6398 | 58 | Inquiry |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | China | 9942 | 58 | Inquiry |
| Wuhan Topule | +86-02787215551 +86-19945035818 | China | 8206 | 58 | Inquiry |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | China | 18488 | 58 | Inquiry |