Midazolam
- CAS No.
- 59467-70-8
- Chemical Name:
- Midazolam
- Synonyms
- 5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(;8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam;Midazolam-d;MidazolaM-d7;MidazolaM API;MIDAZOLAM,BP,EP;Midazolam (CRM);MidazolamBaseE.P;Midazolam solution
- CBNumber:
- CB3418581
- Molecular Formula:
- C18H13ClFN3
- Molecular Weight:
- 325.77
- MOL File:
- 59467-70-8.mol
- Modify Date:
- 2023/6/8 9:02:38
| Melting point | 161-164°C |
|---|---|
| Boiling point | 496.9±55.0 °C(Predicted) |
| Density | 1.3136 (estimate) |
| Flash point | 9 °C |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol. |
| form | Solid:crystalline |
| pka | pKa 1.7±0.1;6.15± 0.1 (Uncertain) |
| Water Solubility | 54mg/L(24 ºC) |
| BCS Class | 1 |
| LogP | 2.73 |
| CAS DataBase Reference | 59467-70-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Midazolam(59467-70-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933910000 | |||||||||
| DEA Controlled Substances | CSCN: 2884 CAS SCH: IV NARC: N |
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| NFPA 704 |
|
Midazolam Chemical Properties,Uses,Production
Description
Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.
Chemical Properties
White Crystaline Solid
Uses
In many countries this product is controlled. An import permit may be required. Anesthetic; anticonvulsant; sedative; hypnotic
General Description
Midazolam is a benzodiazepine, sold as Dormicum, Hypnovel?, and Versed as a sedative and treatment for insomnia and seizures. This Snap-N-Spike? Reference Solution is suitable for many GC/MS or LC/MS applications from clinical toxicology and urine drug testing to pain prescription monitoring or forensic analysis.
Pharmacokinetics
Midazolam undergoes hepatic oxidative metabolism and has an elimination half-life of 2–4h. The major metabolite is 1-hydroxymidazolam, which is biologically active. Midazolam has been used as a sole hypnotic for TI VA and produces superior procedural amnesia compared with propofol, but CSHT increases significantly when used by continuous infusion, and this delays recovery. Clinical studies demonstrate the inferiority of midazolam in terms of time to onset of desired sedation score, slower recovery, less clear-headedness, and significantly longer period of postoperative amnesia compared with propofol.
Midazolam Preparation Products And Raw materials
Raw materials
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