Methyl 2-oxoacetate
- CAS No.
- 922-68-9
- Chemical Name:
- Methyl 2-oxoacetate
- Synonyms
- METHYL GLYOXYLATE;Acetic acid, oxo-, methyl ester;Methyl glyoxalate;Oxoacetic acid methyl ester;GAME;Methyl oxoacetate;Methyl 2-oxoacetate;methyl 2-oxoethanoate;oxo-aceticacimethylester;GLYOXYLIC ACID METHYL ESTER
- CBNumber:
- CB4302241
- Molecular Formula:
- C3H4O3
- Molecular Weight:
- 88.06
- MOL File:
- 922-68-9.mol
- Modify Date:
- 2024/12/18 14:08:52
| Melting point | 40-42°C |
|---|---|
| Boiling point | 102.98°C (rough estimate) |
| Density | 1.2076 (rough estimate) |
| refractive index | 1.3720 (estimate) |
| solubility | sol H2O; sol most organic solvents, e.g. ether, CH2Cl2, THF, acetone, etc. |
| CAS DataBase Reference | 922-68-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl glyoxylate(922-68-9) |
| EPA Substance Registry System | Acetic acid, oxo-, methyl ester (922-68-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H226-H335-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
Methyl 2-oxoacetate Chemical Properties,Uses,Production
Uses
Methyl Glyoxylate is a useful compound for preparation of pyridine and quinoline derivatives.
Preparation
Preparative Methods of Methyl 2-oxoacetate: efficient methods include oxidative cleavage of tartrate diesters, ozonolysis of maleate/fumarate derivatives, exchange reaction between appropriate dialkoxyacetate and glyoxylic acid, and NaOAc-catalyzed elimination of nitrite ion from nitrate esters.[1]
General Description
Methyl Glyoxylate is a two-carbon synthon utilized in electrocyclic processes (Diels-Alder reaction, ene reactions), various condensations (Mannich, aldol, Wittig, Prins, acyloin), carbinolamine formation, and Friedel-Crafts reactions.
storage
Methyl 2-oxoacetate stores under N2 in a refrigerator due to their tendency to form a monohydrate and/or polymerize.
References
1. (a) Wolf, F. J.; Weijland, J. OSC 1963, 4, 124. (b) Jung, M. E.; Shishido, K.; Davis, L. H. JOC 1982, 47, 891. (c) Blake, J.; Tretter, J. R.; Juhasz, G. J.; Bonthrone, W.; Rappoport, H. JACS 1966, 88, 4061. (d) Haggerty, J. G.; Kelly, T. R.; Schmidt, T. E. S 1972, 544. Hook, J. M. SC 1984, 14, 83. (e) Kornblum, N.; Frazier, H. W. JACS 1966, 88, 865.
Methyl 2-oxoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19805 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | China | 226 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | China | 9642 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
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