Dimenhydrinate
- CAS No.
- 523-87-5
- Chemical Name:
- Dimenhydrinate
- Synonyms
- emes;epha;gravol;vomexa;dramyl;dromyl;emedyl;faston;DiMate;amosyt
- CBNumber:
- CB4308768
- Molecular Formula:
- C17H21NO.C7H7ClN4O2
- Molecular Weight:
- 469.97
- MOL File:
- 523-87-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
| Melting point | 102-107°C |
|---|---|
| Density | 1.2586 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Slightly soluble (0.1-1 g/100 mL at 22 ºC) |
| Stability | Hygroscopic |
| InChIKey | NFLLKCVHYJRNRH-UHFFFAOYSA-N |
| CAS DataBase Reference | 523-87-5(CAS DataBase Reference) |
| EPA Substance Registry System | Dimenhydrinate (523-87-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-61-36/37/38 |
| Safety Statements | 22-26-36/37/39-53 |
| WGK Germany | 3 |
| RTECS | XH5082000 |
| TSCA | Yes |
| HS Code | 2939590000 |
Dimenhydrinate Chemical Properties,Uses,Production
Description
Dimenhydrinate (16.1.2) is a complex compound of N, N-dimethyl (2- diphenylmethoxy)ethylamine—diphenhydramine with 8-chlorotheophylline. While blocking the H1 receptor, dimenhydrinate simultaneously acts on the vomiting center.
Chemical Properties
White Solid
Dimenhydrinate is freely soluble in ethanol and chloroform, slightly soluble in water, and almost in-soluble in ether.
Uses
Dimenhydrinate is used for preventing and stopping sea or airsickness, and for nausea and vomiting. Synonyms of this drug are dramamine, dadalon, emedyl, travelin, and others.
Definition
ChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.
General Description
The 8-chlorotheophyllinate (theoclate) salt of diphenhydramine, 8-chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine (Dramamine), is a white crystalline, odorless powder that is highly soluble in water and freely soluble in alcohol and chloroform. Dimenhydrinate is recommended for nausea of motion sickness and for hyperemesis gravidarum (nausea of pregnancy).
Air & Water Reactions
Slightly soluble in water. Slightly acidic.
Health Hazard
SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.
Fire Hazard
Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A drug much used for motion sickness. Human systemic effects by ingestion: arrhythmias, convulsions, distorted perceptions, hallucinations, intracranial pressure increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. See also AMINES.
Dimenhydrinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shreenath Chemicals | +91-8369634120 +91-8369634120 | Maharashtra, India | 48 | 58 | Inquiry |
| S S Pharmachem | +91-9324209894 +91-9702111022 | Maharashtra, India | 20 | 58 | Inquiry |
| Amar Healthcare | +91-9824100314 +91-9512041602 | Gujarat, India | 34 | 58 | Inquiry |
| Medinex Laboratories Pvt Ltd | +91-2782883162 +91-2782883161 | Maharashtra, India | 20 | 58 | Inquiry |
| Harika Drugs Pvt Ltd | +91-4023814863 +91-4023814863 | Telangana, India | 19 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Shreenath Chemicals | 58 |
| S S Pharmachem | 58 |
| Amar Healthcare | 58 |
| Medinex Laboratories Pvt Ltd | 58 |
| Harika Drugs Pvt Ltd | 58 |
| AKASH PHARMA EXPORTS | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
523-87-5(Dimenhydrinate)Related Search:
1of4
chevron_right