Carnosic acid
- CAS No.
- 3650-09-7
- Chemical Name:
- Carnosic acid
- Synonyms
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid;salvin;carnosicaci;carosic acid;CARNOSIC ACID;CARNOSOLIC ACID;CARNOSIC ACID(P);CARNOSIC ACID(RG);Carnosic Acid >carnosic acid oil
- CBNumber:
- CB4367749
- Molecular Formula:
- C20H28O4
- Molecular Weight:
- 332.43
- MOL File:
- 3650-09-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/11 18:14:38
| Melting point | 190°C(lit.) |
|---|---|
| Boiling point | 506.4±50.0 °C(Predicted) |
| Density | 1.184±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 4.14±0.40(Predicted) |
| color | yellow |
| BRN | 2707918 |
| InChIKey | QRYRORQUOLYVBU-VBKZILBWSA-N |
| LogP | 5.405 (est) |
| CAS DataBase Reference | 3650-09-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
Carnosic acid price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2208 | Carnosic Acid Pharmaceutical Secondary Standard; Certified Reference Material | 3650-09-7 | 20MG | ₹14483.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0609 | Carnosic acid from Rosmarinus officinalis ≥91%, powder | 3650-09-7 | 10MG | ₹11875.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 91209 | Carnosic acid analytical standard | 3650-09-7 | 5MG | ₹22602.6 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C3477 | Carnosic Acid | 3650-09-7 | 20MG | ₹3700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C3477 | Carnosic Acid | 3650-09-7 | 100MG | ₹9900 | 2022-05-26 | Buy |
Carnosic acid Chemical Properties,Uses,Production
Chemical Properties
Yellow powder
Uses
Carnosic Acid is a phenolic component of rosemary. It acts as a potent antioxdant and also has UV protective activity. Specifically protection for UV-A radiation and damage. Carnosic Acid also inhibits the free-radical chain reaction that leads to the oxidation of fats and oils, thereby stabilizing and increasing the shelf life of meats.
Definition
ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Anticancer Research
Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).
Carnosic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Phytotech Extract Pvt Ltd | +91-7829650999 +91-7829650999 | Karnataka, India | 10 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +8618374838656 | China | 1025 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 292 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1142 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
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