ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >Disodium clodronate tetrahydrate
Disodium clodronate tetrahydrate
- CAS No.
- 88416-50-6
- Chemical Name:
- Disodium clodronate tetrahydrate
- Synonyms
- Clodronate (sodium salt hydrate);BONEFOS;CLASTEON;CLASTOBAN;CLODRONATE DISODIUM SALT;Ceftobiprole Impurity 11;Disodium clodronate tetrahydrate;Clodronate disodiuM(tetrehydrate);DisodiumClodronateTetrahydrate>CLODRONATE, DISODIUM, TETRAHYDRATE
- CBNumber:
- CB4404653
- Molecular Formula:
- CH7Cl2NaO7P2
- Molecular Weight:
- 286.9
- MOL File:
- 88416-50-6.mol
- Modify Date:
- 2023/9/20 18:48:35
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in Water (up to at least 10 mg/ml) |
| form | White solid |
| color | White |
| Merck | 14,2371 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | XWHPUCFOTRBMGS-UHFFFAOYSA-L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361-H332-H412-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P273-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| RTECS | SZ7640700 | |||||||||
| HS Code | 2931.39.0030 | |||||||||
| NFPA 704 |
|
Disodium clodronate tetrahydrate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 233183 | Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. | 88416-50-6 | 10MG | ₹15280 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4160 | Disodium Clodronate Tetrahydrate | 88416-50-6 | 1G | ₹5500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4160 | Disodium Clodronate Tetrahydrate | 88416-50-6 | 5G | ₹18200 | 2022-05-26 | Buy |
Disodium clodronate tetrahydrate Chemical Properties,Uses,Production
Description
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.
Uses
Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.
Definition
ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.
Disodium clodronate tetrahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Disodium clodronate tetrahydrate Suppliers
Global( 130)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
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