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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >Disodium clodronate tetrahydrate

Disodium clodronate tetrahydrate

Disodium clodronate tetrahydrate Structure
  • ₹5500 - ₹18200
  • Product name: Disodium clodronate tetrahydrate
  • CAS: 88416-50-6
  • MF: CH7Cl2NaO7P2
  • MW: 286.9
  • EINECS:
  • MDL Number:MFCD02940846
  • Synonyms:DICHLOROMETHYLENE-BISPHOSPHONATE, DISODIUM TETRAHYDRATE;CLASTEON;CLASTOBAN;CLODRONIC ACID, DISODIUM SALT, TETRAHYDRATE;CLODRONATE DISODIUM SALT;CLODRONATE, DISODIUM SALT, TETRAHYDRATE;CLODRONATE, DISODIUM, TETRAHYDRATE;BONEFOS
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberD4160
  • Product descriptionDisodium Clodronate Tetrahydrate
  • Packaging1G
  • Price₹5500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD4160
  • Product descriptionDisodium Clodronate Tetrahydrate
  • Packaging5G
  • Price₹18200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number233183
  • Product descriptionClodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.
  • Packaging10MG
  • Price₹15280
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D4160 Disodium Clodronate Tetrahydrate 1G ₹5500 2022-05-26 Buy
TCI Chemicals (India) D4160 Disodium Clodronate Tetrahydrate 5G ₹18200 2022-05-26 Buy
Sigma-Aldrich(India) 233183 Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. 10MG ₹15280 2022-06-14 Buy

Properties

storage temp. :2-8°C
solubility :Soluble in Water (up to at least 10 mg/ml)
form :White solid
color :White
Merck :14,2371
Stability :Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
InChIKey :XWHPUCFOTRBMGS-UHFFFAOYSA-L

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P281 Use personal protective equipment as required.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.

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