REVEROMYCIN A

REVEROMYCIN A Structure
CAS No.
134615-37-5
Chemical Name:
REVEROMYCIN A
Synonyms
REVEROMYCIN A;ZESGNAJSBDILTB-OXVOKJAASA-N;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
CBNumber:
CB4443481
Molecular Formula:
C36H52O11
Molecular Weight:
660.79
MOL File:
134615-37-5.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:09

REVEROMYCIN A Properties

Boiling point 849.0±65.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMF: soluble
form solid
pka 4.36±0.17(Predicted)
color tan

SAFETY

Risk and Safety Statements

WGK Germany  3

REVEROMYCIN A price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R0654 Reveromycin A solid 134615-37-5 100μG ₹30558.98 2022-06-14 Buy
Product number Packaging Price Buy
R0654 100μG ₹30558.98 Buy

REVEROMYCIN A Chemical Properties,Uses,Production

Uses

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF. Reveromycin A is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.

REVEROMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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REVEROMYCIN A ZESGNAJSBDILTB-OXVOKJAASA-N Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester 134615-37-5 C36H52O11 BioChemical Antibiotics Antibiotics A to Z Antibiotics N-S Epidermal Growth Factor Receptor (EGFR)Antibiotics Interferes with Protein Synthesis Antibiotics Antibiotics A to Antibiotics by Application Antibiotics N-SAntibiotics AntifungalAntibiotics Mechanism of Action Receptor Tyrosine Kinase Inhibitors Spectrum of Activity Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology