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ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Pancreatic hormone and blood sugar regulation >Voglibose

Voglibose

Voglibose Structure
CAS No.
83480-29-9
Chemical Name:
Voglibose
Synonyms
5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol;Basen;Jumeal;AO 128;A 71100;Glustat;Beigrace;Voglistat;VOGLIBOSE;Voglibose D5
CBNumber:
CB4481287
Molecular Formula:
C10H21NO7
Molecular Weight:
267.28
MOL File:
83480-29-9.mol
MSDS File:
SDS
Modify Date:
2024/4/24 17:21:45
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Voglibose Properties

Melting point 162-163°C
alpha D25 +26.2° (c = 1 in water)
Boiling point 601.9±55.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO (Slightly), Methanol (Very Slightly, Heated), Water (Sparingly, Sonicated)
form Solid
pka 13.26±0.70(Predicted)
color White to Off-White
Merck 14,10029
InChIKey FZNCGRZWXLXZSZ-CIQUZCHMSA-N
CAS DataBase Reference 83480-29-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  36/37-37/39-26
WGK Germany  3
RTECS  NM7524600
HS Code  2940.00.6000

Voglibose price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 50359 Voglibose ≥97.0% (TLC) 83480-29-9 10MG ₹24616.05 2022-06-14 Buy
TCI Chemicals (India) V0119 Voglibose 83480-29-9 100MG ₹10900 2022-05-26 Buy
SRL 40996 Voglibose extrapure, 98% 83480-29-9 100mg ₹4870 2022-05-26 Buy
SRL 40996 Voglibose extrapure, 98% 83480-29-9 500mg ₹16230 2022-05-26 Buy
Product number Packaging Price Buy
50359 10MG ₹24616.05 Buy
V0119 100MG ₹10900 Buy
40996 100mg ₹4870 Buy
40996 500mg ₹16230 Buy

Voglibose Chemical Properties,Uses,Production

Description

Voglibose was introduced in Japan for the treatment of postprandial hyperglycemia in diabetic patients. As an orally active α-D-glucosidase inhibitor, it is effective in decreasing the release of glucose from carbohydrate ingestion and slowing the increase of postprandial blood glucose levels, as demonstrated in animals and humans following sucrose and starch loading. In addlion, voglibose was reported to have prophylactic effect in genetically obese Wistar rats, maintaining low plasma levels of glucose, triglyceride and insulin, indicating a potential usefulness for the management of other carbohydrate-dependent metabolic disorders such as obesity. Voglibose is much more potent and has fewer side effects than acarbose, another agent in its class.

Chemical Properties

Colourless Crystalline Solid

Uses

Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway.

World Health Organization (WHO)

Acarbose and voglibose area-glucosidase inhibitors and delay digestion/absorption of carbohydrates as well as improving postprandial hyperglycaemia.

General Description

The most potent -glucosidase inhibitor is the valiolamine derivative voglibose. Compared with acarbose its inhibitory potency in vitro, depending on the -glucosidase enzyme, is up to 200 times higher. In Japan, daily dosages are only 0.3 – 0.9 mg, however, therapeutic efficacy on HbA1c reduction could not be clearly demonstrated with those dosages. HbA1c, a glycated hemoglobin species, which occurs in blood, is a diagnostic measure for the non-enzymatic glycation process, and depends on the plasma glucose concentration. The process of protein glycation is discussed to be responsible for the development of diabetic complications (neuropathy, retinopathy, nephropathy). In Europe voglibose is under evaluation with distinctly higher daily dosages of 1.5 to 6 mg. In contrast to acarbose, the smaller inhibitors of the monosaccharide type (miglitol, emiglitate, voglibose) do not inhibit pancreatic -amylase.

Biological Activity

Orally active α -glucosidase inhibitor (IC 50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo .

Voglibose Preparation Products And Raw materials

Raw materials

Sodium cyanoborohydride DOWEX 50WX4-200R ION-EXCHANGE RESIN 1,3-Dihydroxyacetone Valiolamine AMBERLITE
Valienamine (2R,3S,4S,5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone Tetrabenzyl-voglibose
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Preparation Products

Voglibose Suppliers

Global( 526)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Anthem Biosciences Pvt Ltd +91-8066724000 +91-9900044575 Karnataka, India 38 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Horster Biotek Pvt Ltd +91-7359657360 +91-9898127219 Gujarat, India 58 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Alfa Omega Pharma +91-8050045945 +91-9972665399 Maharashtra, India 126 58 Inquiry
Beloorbayir Biotech Ltd +91-8792661159 +91-8867683718 Karnataka, India 25 58 Inquiry
Allastir Private Limited +91-9840051621 +91-9791039207 Tamil Nadu, India 15 58 Inquiry
Indexim International 08048971004 Gujarat, India 112 58 Inquiry
Rag Healthcare 08048372836Ext 550 Gujarat, India 19 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
Anthem Biosciences Pvt Ltd 58
Hetero Drugs Limited 58
Horster Biotek Pvt Ltd 58
Ralington Pharma 58
Alfa Omega Pharma 58
Beloorbayir Biotech Ltd 58
Allastir Private Limited 58
Indexim International 58
Rag Healthcare 58

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Voglibose Spectrum

Voglibose(83480-29-9)MS

83480-29-9(Voglibose)Related Search:

Cyclohexanone Acetaminophen Tris(hydroxymethyl)aminomethane Molasses Trimethylolpropane
Cyclohexane Glibornuride TETRABENZYL-VOGLIBOSE (R)-Valiolamine Voglibose D-epi-Inositol, 1-O-(cyclohexylmethyl)-3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)- (9CI)
Acarbose Miglitol Pioglitazone hydrochloride D-epi-Inositol, 2-C-[(cyclohexylmethoxy)methyl]-3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]- (9CI) Valiolamine
(S)-Valiolamine Voglibose Cyclohexanone Impurity 3 D-epi-Inositol, 6-O-(cyclohexylmethyl)-3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)- (9CI)
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Voglistat epi-Inositol, 2,3-dideoxy-2-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-4-C-(hydroxymethyl)- 2,3-Dideoxy-2-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-4-C-(hydroxymethyl)-epi-inositol Beigrace Jumeal Voglibose ,98% 3,4-Dideoxy-4-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-D-epi-inositol N-(1,3-Dihydroxyprop-2-yl)valiolamine (1S,2S,3R,4S,5S)-5-[(1,3-dihydroxypropan-2-yl)aMino]-1-(hydroxyMethyl)cyclohexane-1,2,3,4-tetrol D-epi-Inositol, 3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl) Voglibose 5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol VOGLIBOSE 3,4-DIDEOXY-4-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]AMINO]-2-C-(HYDROXYMETHYL)-D-EPIINOSITOL 3,4-DIDEOXY-4-[[2-HYDROXY-1-(HYDROXYMETHYL)ETHYL]AMINO]-2-C-(HYDROXYMETHYL)-D-EPINOSITOL VOGLIBOSE, 99+% N-(1,3-Dihydroxyprop-2-yl)valiolamine, 3,4-Dideoxy-4-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-D-epi-inositol A 71100 AO 128 D-epi-Inositol, 3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)- (9CI) Glustat N-(1,3-Dihydroxy-2-propyl)valiolamine Voglibose Solution, 100ppm Voglibose Voglibose (1S,2S,3R,4S,5S)-5-((1,3-Dihydroxypropan-2-yl)amino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol Voglibose USP/EP/BP 5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-Tetro Voglibose D5 VogliboseQ: What is Voglibose Q: What is the CAS Number of Voglibose Q: What is the storage condition of Voglibose Q: What are the applications of Voglibose Voglibose CP GRADE Voglibose extrapure, 98% 5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol Basen Voglibose Impurity 34 83480-29-9 480-29-9 3480-29-9 C10H21NO6 C10H21NO7 Diabetes Research Carbohydrates & Derivatives Miscellaneous VOGLIBOSE All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals API 83480-29-9