NU 2058
- CAS No.
- 161058-83-9
- Chemical Name:
- NU 2058
- Synonyms
- CS-2601;NU2058>2-aMino-6-purine;NU 2058;NU-2058;NU2058;O-Cyclohexylmethylguanine;2-Amino-6-(cyclohexylmethoxy)purine;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-[(cyclohexylMethyl)oxy]purine;9H-Purin-2-amine, 6-(cyclohexylmethoxy)-
- CBNumber:
- CB4498289
- Molecular Formula:
- C12H17N5O
- Molecular Weight:
- 247.3
- MOL File:
- 161058-83-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 199°C(lit.) |
|---|---|
| Boiling point | 424.8±55.0 °C(Predicted) |
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: 22 mg/mL |
| form | powder to crystal |
| pka | 7.36±0.20(Predicted) |
| color | white |
| λmax | 281nm(MeOH)(lit.) |
| InChIKey | MWGXGTJJAOZBNW-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.9000 | |||||||||
| NFPA 704 |
|
NU 2058 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N4286 | NU2058 >98% (HPLC) | 161058-83-9 | 5MG | ₹17612.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0958 | NU 2058 | 161058-83-9 | 20MG | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0958 | NU 2058 | 161058-83-9 | 100MG | ₹14400 | 2022-05-26 | Buy |
NU 2058 Chemical Properties,Uses,Production
Description
NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.
Uses
NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.
Biological Activity
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).
NU 2058 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | China | 3000 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
161058-83-9(NU 2058)Related Search:
1of4
chevron_right