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Liranaftate

CAS No.: 88678-31-3

Chemical Name:: Liranaftate

Synonyms: LNF;M-732;ZEFNART;LIRANAFATE;LIANAFTATE;LIRANAFTATE;PIRITETRATE;LIRANAFTATO;Liranaftatum;phthalenyl)ester

CBNumber:: CB5168482

Molecular Formula:: C18H20N2O2S

Molecular Weight:: 328.43

MOL File:: 88678-31-3.mol

Modify Date:: 2024/4/23 17:50:46

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Liranaftate Properties

Melting point	98.5-99.5°C
Boiling point	462.5±55.0 °C(Predicted)
Density	1.240±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	1.24±0.10(Predicted)
color	Off-White
Merck	14,5515

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H317

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

RTECS

FD3890000

HS Code

2933.39.4100

NFPA 704

	0
2		0

Liranaftate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	L0301	Liranaftate	88678-31-3	50MG	₹3200	2022-05-26	Buy
TCI Chemicals (India)	L0301	Liranaftate	88678-31-3	250MG	₹8200	2022-05-26	Buy

Product number	Packaging	Price	Buy
L0301	50MG	₹3200	Buy
L0301	250MG	₹8200	Buy

Liranaftate Chemical Properties,Uses,Production

Description

Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.

Chemical Properties

White Crystalline Solid

Liranaftate Preparation Products And Raw materials

Raw materials

Preparation Products

Liranaftate Suppliers

Global( 342)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
ARCHERCHEM	91-22-28786843/ 91-22-28786842 /91-22-28786842	New Delhi, India	86	54	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12460	58	Inquiry
Ouhuang Engineering Materials (Hubei) Co., Ltd	+86-86177	China	2952	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry

Supplier	Advantage
TCI Chemicals (India) Pvt. Ltd.	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
ARCHERCHEM	54
Hebei Mojin Biotechnology Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

Liranaftate Spectrum

Liranaftate(88678-31-3)¹HNMR

88678-31-3(Liranaftate)Related Search:

N-Aminothiourea Thiobenzoic acid Dithiooxamide 4-Methoxybenzoic acid Phenyl chlorothionocarbonate

2-(Trifluoromethoxy)aniline Ciclopirox ethanolamine Tolnaftate Terbinafine Hydrochloride PEN

5,6,7,8-TETRAHYDRO-2-NAPHTHOL/INTERMEDIATE OF LIRANAFTATE 2-Amino-6-methoxypyridine PYRIDINE, 2-METHOXY-6-METHYAMINO-(INTERMEDIATES OF LIRANAFTATE) Liranaftate O-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL) CHLOROTHIOCARBONATE[FOR LIRANAFTATE]

2-METHOXY-6-METHYLAMINOPYRIDINE/INTERMEDIATE OF LIRANAFTATE AMMONIUM THIOCARBAMATE

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LNF O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na phthalenyl)ester LIRANAFATE LIRANAFTATE M-732 (6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER PIRITETRATE ZEFNART (6-Methoxy-2-pyridinyl)-methylcarbamothioic Acid O-(5,6,7,8-Tetrahydro-2-naphthalenyl) Ester, Piritetrate, M-732, Zefnart LIANAFTATE LIPOPEPTIDEACETATE (6-Methoxy-2-pyridinyl)-MethylcarbaMothioic Acid O-(5,6,7,8-Tetrahydro-2-naphthyl) N-(6-Methoxy-2-pyridyl)-N-MethylthiocarbaMate Piritetrate, M-732, Zefnart Carbamothioic acid, (6-methoxy-2-pyridinyl)methyl- O-(5,6,7,8-tetrahydro-2-naphthalenyl)ester N-(6-Methoxy-2-pyridinyl)-N-methylthiocarbamic acid O-[(5,6,7,8-tetrahydronaphthalen)-2-yl] ester N-(6-Methoxy-2-pyridyl)-N-methylthiocarbamic acid O-(5,6,7,8-tetrahydronaphthalene-2-yl) ester N-(6-methoxy-2-pyridinyl)-N-methyl-carbamothioic acid-o-(5,6,7,8-tetrahydro-2-naphthalenyl) ester Liranaftatum Carbamothioic acid, N-(6-methoxy-2-pyridinyl)-N-methyl-, O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester (6-Methoxypyridin-2-yl)(methyl)carbamothioic Acid O-(5,6,7,8-Tetrahydronaphthalen-2-yl) Ester O-(5,6,7,8-Tetrahydronaphthalen-2-yl) (6-Methoxypyridin-2-yl)(methyl)carbamothioate Liranaftate USP/EP/BP LIRANAFTATO Liranaftate (Piritetrate LiranaftateQ: What is Liranaftate Q: What is the CAS Number of Liranaftate Q: What is the storage condition of Liranaftate Q: What are the applications of Liranaftate Leila naphthalene ester 88678-31-3 8867-31-3 C18H20N2O2S API Liranaftate Inhibitors Intermediates & Fine Chemicals Pharmaceuticals All Inhibitors 88678-31-3