Liranaftate manufacturers and suppliers in india

Liranaftate

Properties

Melting point:: 98.5-99.5°C

Boiling point:: 462.5±55.0 °C(Predicted)

Density: 1.240±0.06 g/cm3(Predicted)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: DMSO (Slightly), Methanol (Slightly, Heated)

form: Solid

pka: 1.24±0.10(Predicted)

color: Off-White

Merck: 14,5515

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319-H315-H317

Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

RTECS: FD3890000

HS Code: 2933.39.4100

Use

Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.