Liranaftate
Liranaftate
- CAS:
- 88678-31-3
- MF:
- C18H20N2O2S
- MW:
- 328.43
Suppliers by country/region
Company Type
Properties
- Melting point:
- 98.5-99.5°C
- Boiling point:
- 462.5±55.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 1.24±0.10(Predicted)
- color
- Off-White
- Merck
- 14,5515
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H319-H315-H317
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
- RTECS
- FD3890000
- HS Code
- 2933.39.4100
Use
Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6,7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
3 India supplier list of "Liranaftate"
- Product Name:Liranaftate
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Liranaftate
- Products Intro:Brand:pharmaffiliates | Product Number:PA6516000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Liranaftate
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: carbomer,lead acetate,phenylacetamide,Xylazine,Xylazine hcl
$0.00/ 25KG