Modafinil
- CAS No.
- 68693-11-8
- Chemical Name:
- Modafinil
- Synonyms
- Provigi;Modiodal;CEP 1538;DEP 1538;MODAFINIL;CRC 40476;CRL-40476;Modaphonil;F9Modafinil;Modafinilrac
- CBNumber:
- CB5223833
- Molecular Formula:
- C15H15NO2S
- Molecular Weight:
- 273.35
- MOL File:
- 68693-11-8.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 164-166°C |
|---|---|
| Boiling point | 559.1±50.0 °C(Predicted) |
| Density | 1.283±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | Store at +4°C |
| solubility | DMSO: 18 mg/mL, soluble |
| form | white solid |
| pka | 14.88±0.40(Predicted) |
| color | white |
| BCS Class | 4 |
| CAS DataBase Reference | 68693-11-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361d | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | T+,Xn,F | |||||||||
| Risk Statements | 26/27/28-36-20/21/22-11 | |||||||||
| Safety Statements | 24/25-45-36/37/39-22-36/37-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
Modafinil Chemical Properties,Uses,Production
Description
Modafinil, a centrally active α1-adrenergic agonist, was marketed in France as a psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia including Gelineau's syndrome. In monkeys, modafinil was found to induce potent behavioral stimulation and awakening without stereotyped behavior. In narcoleptic patients, modafinil reduces the daily number of sleep attacks significantly and markedly improves performance. The mechanism of action for its locomotor effects was reported to be due to the stimulation of the central α1-adrenergic system, opposite to amphetamine and methylphenidate, which act mainly by dopaminergic mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects at therapeutic doses and appears to have low abuse potential. The use of modafinil in the treatment of cerebral infarction and ischemia has been claimed.
Chemical Properties
Crystalline Solid
Uses
Modafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
General Description
Modafinil (Provigil) has overall wakefulness-promotingproperties similar to those of central sympathomimetics. It isconsidered an atypical α1-norepinephrine (NE) receptorstimulant and is used to treat daytime sleepiness in narcolepsypatients. Adverse reactions at therapeutic doses arereportedly not severe and may include nervousness, anxiety,and insomnia. Modafinil is used by oral administration.
Biological Activity
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Modafinil Preparation Products And Raw materials
Raw materials
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