ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >PF-04929113

PF-04929113

CAS No.: 908115-27-5

Chemical Name:: PF-04929113

Synonyms: CS-33;snx54227;SNX-5422;PF-04929113;PF-04929113, >=98%;PF04929113 SNX-54227;PF-04929113(SNX5422);snx5422 PF 04929113;PF-04929113 USP/EP/BP;PF-04929113 SNX-5422 PF04929113 SNX5422

CBNumber:: CB52561489

Molecular Formula:: C25H30F3N5O4

Molecular Weight:: 521.53

MOL File:: 908115-27-5.mol

Modify Date:: 2024/7/2 8:55:11

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PF-04929113 Properties

Melting point	298-299℃
Boiling point	646.5±55.0 °C(Predicted)
Density	1.48
storage temp.	Store at -20°C
solubility	≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form	solid
pka	15.07±0.50(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

PF-04929113 Chemical Properties,Uses,Production

Uses

PF 04929113 can be used in pharmacological activity and therapeutic use in therapeutic breast cancer drug target for multiclass comparative virtual screening to identify novel Hsp90 inhibitors. HSP90

Enzyme inhibitor

This potent and selective HSP90 inhibitor (FW = 521.54 g/mol; CAS 908115-27-5; Solubility: 100 mg/mL DMSO, <1mg/mL H2O), also knownas SNX-5422 and (1R,4R)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3- (trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2- aminoacetate, targets heat shock protein-90 (Kd = 41 nM) and also inhibits Her-2 degradation (IC50 = 37 nM). PF-04929113 also shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50 =16 nM), SW620 (IC50 =19 nM), K562 (IC50 =23 nM), SK-MEL-5 (IC50 =25 nM), and A375 (IC50 =51 nM). SNX2112 inhibits in vitro proliferation, inducing G2/M arrest, and enhanced cytotoxicity, chemosensitivity, and radiosensitivity between 25 and 250 nM, decreasing expression and/or phosphorylation of EGFR, c-MET, AKT, ERK-1 and -2, IκB kinase, and STAT3, corresponding downstream NFκB, AP-1, and STAT3 reporter genes, and target oncogenes and angiogenic cytokines.

PF-04929113 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-04929113 Suppliers

Global( 92)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

PF-04929113 Spectrum

PF-04929113(908115-27-5)¹HNMR

908115-27-5(PF-04929113)Related Search:

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(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate PF-04929113, >=98% snx54227 PF04929113 SNX-54227 PF-04929113 SNX-5422 PF-04929113(SNX5422) Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester CS-33 SNX5422;PF 04929113;SNX 5422;PF-04929113; (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate snx5422 PF 04929113 PF-04929113 USP/EP/BP trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate PF-04929113 SNX-5422 PF04929113 SNX5422 908115-27-5 C25H30F3N5O4 Inhibitors Inhibitor