Oxamic acid sodium salt
- CAS No.
- 565-73-1
- Chemical Name:
- Oxamic acid sodium salt
- Synonyms
- SODIUM OXAMATE;oxamate sodium;Grass sodiuM acid;oxamic acid sodium;Oxamate Sodium Salt;OXAMIC ACID SODIUM SALT;sodium carbamoylformate;sodiuM 2-aMino-2-oxoacetate;Oxamic acid, sodium salt,98%;AMINOOXOACETIC ACID SODIUM SALT
- CBNumber:
- CB5262762
- Molecular Formula:
- C2H2NNaO3
- Molecular Weight:
- 111.03
- MOL File:
- 565-73-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 300 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | solid |
| color | White to off-white |
| Water Solubility | Soluble in water (10 mg/ml). |
| BRN | 6538153 |
| InChI | InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1 |
| InChIKey | RQVZIJIQDCGIKI-UHFFFAOYSA-M |
| SMILES | C(=O)(N)C([O-])=O.[Na+] |
| CAS DataBase Reference | 565-73-1(CAS DataBase Reference) |
| EPA Substance Registry System | Sodium oxamate (565-73-1) |
Oxamic acid sodium salt price More Price(2)
Oxamic acid sodium salt Chemical Properties,Uses,Production
Description
Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.
Chemical Properties
white crystalline powder
Uses
Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research.
Application
Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
Biochem/physiol Actions
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.
in vitro
Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells.
Oxamic acid sodium salt Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 | China | 225 | 58 | Inquiry |
| Hongxiong | +undefined18915499068 | China | 120 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vardhaman P Golechha | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| Clearsynth Labs | 58 |
| Sense Chemicals (Shanghai) Co., Ltd. | 58 |
| Hongxiong | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| career henan chemical co | 58 |