4-HYDROXYISOLEUCINE
- CAS No.
- 55399-93-4
- Chemical Name:
- 4-HYDROXYISOLEUCINE
- Synonyms
- HIL;4-Hydroxyisoleucine;HYDROXYISOLEUCINE, 4-;4 -Hydroxyisoleucic acid;HYDROXYISOLEUCINE, 4-(FG);(4S)-4-Hydroxy-L-isoleucine;Hydroxyisoleucine 55399-93-4;TIANFU-CHEM 4-HYDROXYISOLEUCINE;4-HYDROXYISOLEUCINECAS:55399-93-4;[DISCONTINUED] Replaced by KIT-00008502-0HK
- CBNumber:
- CB5274835
- Molecular Formula:
- C6H13NO3
- Molecular Weight:
- 147.17
- MOL File:
- 55399-93-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/6 18:00:57
| Melting point | 223-224℃ |
|---|---|
| Boiling point | 331.6±32.0 °C(Predicted) |
| Density | 1.181±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 147℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 2.41±0.25(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D +32.5±2.0°, c = 1 in H2O |
| BRN | 4128096 |
| InChI | InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1 |
| InChIKey | OSCCDBFHNMXNME-YUPRTTJUSA-N |
| SMILES | C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
4-HYDROXYISOLEUCINE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 50118 | (4S)-4-Hydroxy-L-isoleucine from fenugreek seeds, ≥98.0% (TLC) | 55399-93-4 | 50MG | ₹36729.23 | 2022-06-14 | Buy |
| ottokemi | H 1633 | (4S)-4-Hydroxy-L-isoleucine 98% | 55399-93-4 | 50mg | ₹38079 | 2022-05-26 | Buy |
4-HYDROXYISOLEUCINE Chemical Properties,Uses,Production
Description
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
Occurrence
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
Uses
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
Definition
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
Biological Activity
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
4-HYDROXYISOLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| ChiRial Biomaterial Co Ltd | +8619951673840 | China | 156 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16221 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7239 | 58 | Inquiry |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
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