Bendamustine
- CAS No.
- 16506-27-7
- Chemical Name:
- Bendamustine
- Synonyms
- 4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid;Bendamustine;4-(5-(Bis(2-chloroethyl);-1-methyl-1H-benzo[d]imidazol-2-yl);5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid;5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-;alkylating,SDX-105,inhibit,DNA Alkylator/Crosslinker,antimetabolite,purine,anticancer,Apoptosis,Bendamustine,SDX 105,Inhibitor,DNA;BendamustineQ: What is Bendamustine Q: What is the CAS Number of Bendamustine Q: What is the storage condition of Bendamustine Q: What are the applications of Bendamustine
- CBNumber:
- CB5340488
- Molecular Formula:
- C16H21Cl2N3O2
- Molecular Weight:
- 358.26
- MOL File:
- 16506-27-7.mol
- Modify Date:
- 2024/7/2 8:55:11
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H341-H351-H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501 |
Bendamustine Chemical Properties,Uses,Production
Uses
Treatment of hematologic cancer, especially non-Hodgkin’s lymphoma.
brand name
Ribomustine (Amcis AG, Switzerland).
Enzyme inhibitor
This nitrogen mustard and anticancer drug (FWfree-acid = 358.26 g/mol; CAS 16506-27-7), also known by its code name SDX-105, its trade names Treanda?, Treakisym?, Ribomustin?, and Levact?, as well as by its systematic name 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2- yl]butanoic acid, is a relatively nonspecific DNA alkylating agent that causes intra- and inter-strand cross-links. Bendamustine is used in the treatment of chronic lymphocytic leukemia (CLL), Hodgkin’s disease, nonHodgkin’s lymphoma, multiple myeloma and lung cancer. Pharmacokinetics: After intravenous infusion, >95% of the drug becomes protein-bound, mainly to albumin; however, only free bendamustine is active. Bendamustine is metabolized by liver cytochrome p450, and elimination (renal) is biphasic, with an initial half-life of 6–10 minutes and a terminal half-life of approximately 30 minutes.
Bendamustine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| NATCO Pharma Limited | +91-9849511345 +91-9866005199 | Hyderabad, India | 24 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Shreyaa Medilife Private Limited | +91-6354474696 +91-9879513108 | Ahmedabad, India | 67 | 58 | Inquiry |
| Fresenius Kabi Oncology Limited | +91-1243325000 +91-1244885000 | Haryana, India | 22 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Rhyme Organics And Chemicals Limited | 08048372046Ext 929 | Hyderabad, India | 102 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |