Ropinirole hydrochloride
- CAS No.
- 91374-20-8
- Chemical Name:
- Ropinirole hydrochloride
- Synonyms
- ROPINIROLE HCL;REQUIP;4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride;Requi;SKF-101468A;Ropinirole HCl API;Ropinirole Hcl ,99%;Ropinirole hydrochlo;Ropinib hydrochloride;Ropinero hydrochloride
- CBNumber:
- CB5420618
- Molecular Formula:
- C16H25ClN2O
- Molecular Weight:
- 296.84
- MOL File:
- 91374-20-8.mol
- Modify Date:
- 2024/3/22 17:12:53
| Melting point | 241-243°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | powder |
| color | light yellow |
| InChI | InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H |
| InChIKey | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
| SMILES | C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl |
| CAS DataBase Reference | 91374-20-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| Hazard Codes | Xn,N,Xi | |||||||||
| Risk Statements | 22-50/53-36/38 | |||||||||
| Safety Statements | 36-60-61-37/39-26 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NM3288250 | |||||||||
| HS Code | 2933790002 | |||||||||
| NFPA 704 |
|
Ropinirole hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R2530 | Ropinirole hydrochloride powder, ≥98% (HPLC) | 91374-20-8 | 25MG | ₹8973.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R2530 | Ropinirole hydrochloride powder, ≥98% (HPLC) | 91374-20-8 | 100MG | ₹40539.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1633 | Ropinirole Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 91374-20-8 | 200MG | ₹19896.35 | 2022-06-14 | Buy |
Ropinirole hydrochloride Chemical Properties,Uses,Production
Description
ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.
Chemical Properties
Off-White Solid
Uses
An antiparkinsonian agent. A selective dopamine D2-receptor agonist
General Description
Ropinirole hydrochloride,4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride(Requip), is a white to pale greenish yellow powder that isvery soluble in water. Ropinirole is rapidly absorbed afteroral administration with maximal plasma concentrationsgenerally reached after about 1.5 hours, and the eliminationhalf-life appears to be approximately 3 hours. Ropinirole isalso rapidly and extensively distributed from the vascularcompartment and shows low plasma protein binding that isindependent of its plasma concentration. This drug iscleared by metabolism in the liver, with only 10% being excretedunchanged. The main metabolite of ropinirole is theN-despropyl metabolite. The glucuronide of this metaboliteand the carboxylic acid metabolite, 4-carboxymethylindolin-2-one, account only for 10% of the administered dose.None of the metabolites is pharmacologically active, and theexcretion of ropinirole-derived products is mainly via theurine. The main CYP450 isozyme involved in the metabolismof ropinirole is CYP1A2. Inhibitors or inducers ofthis enzyme have been shown to alter the clearance ofropinirole.Ropinirole is believed to act as an agonist atpostsynaptic D2 receptors. Ropinirole is indicated for thetreatment of the signs and symptoms of idiopathic PD andmoderate to severe primary RLS.
Biological Activity
Selective D 2 -like receptor agonist (D 3 > D 2 > D 4 ). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.
Ropinirole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| SVK Laboratories Pvt Ltd | +91-40-23095079 +91-9177729915 | Telangana, India | 89 | 58 | Inquiry |
| Synthokem Labs Private Limited | +91-9966400646 +91-9966400646 | Hyderabad, India | 15 | 58 | Inquiry |
| USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) | +91-4428244254 +91-4428244254 | Tamil Nadu, India | 28 | 58 | Inquiry |
| Ind Swift Laboratories Ltd | +91-1126226140 +91-1126226140 | New Delhi, India | 26 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
91374-20-8(Ropinirole hydrochloride)Related Search:
1of4
chevron_right