Cemandil sodium salt
- CAS No.
- 42540-40-9
- Chemical Name:
- Cemandil sodium salt
- Synonyms
- CEFAMANDOLE NAFATE;Fado;CefaM;Cedol;CeMado;Nafate;mandol;Cefiran;Kefadol;Pavecef
- CBNumber:
- CB5430833
- Molecular Formula:
- C19H17N6NaO6S2
- Molecular Weight:
- 512.49
- MOL File:
- 42540-40-9.mol
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 190-193°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Freely soluble in water, sparingly soluble in methanol. |
| form | Solid |
| pka | 2.6-3.0(at 25℃) |
| color | White to Off-White |
| Water Solubility | Freely soluble in water. Sparingly soluble in methanol |
| CAS DataBase Reference | 42540-40-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P280-P284-P304+P340-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-42/43 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XI0380000 | |||||||||
| HS Code | 2941906000 | |||||||||
| NFPA 704 |
|
Cemandil sodium salt Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Cephalosporin antibacterial.
Definition
ChEBI: A cephalosporin prodrug having (R)-O-formylmandelamido and N-methylthiotetrazole side-groups.
Mechanism of action
Cefamandole nafate has a formylated D-mandelic amide moiety at C-7. The formate ester is cleaved rapidly in the host to release the more active cefamandole. The esterification also apparently overcomes the instability of cefamandole when it is stored in dry form. This agent has increased activity against Haemophil us influenzae and some Gram-negative bacilli as compared with the first-generation cephalosporins. Loss of the 5-thio-l-methyl-l-H-tetrazole moiety (referred to sometimes by the acronym MT T) from C-3 is associated with prothrombin deficiency and bleeding problems as well as with an Antabuse-like acute alcohol intolerance. On the other hand, this grouping enhances potency and prevents metabolism by deacetylation. Like the other second-generation cephalosporins, cefamandole is more active against Gram-negative bacteria. The principle clinical use is for lower respiratory tract, skin and skin structures, and bone and joint infections as well as septicemia and urinary tract infections when the organisms are sensitive.
Clinical Use
The D-mandeloyl moiety of Cemandil sodium salt appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.
Cemandil sodium salt Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
| Nakshatra Chemicals | 09819631316 | Mumbai, India | 162 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Vitus Global Inc | 91-11-40516279 | Delhi, India | 91 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | China | 1142 | 58 | Inquiry |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | China | 299 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |