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CYCLOTHIAZIDE

CAS No.: 2259-96-3

Chemical Name:: CYCLOTHIAZIDE

Synonyms: Lil;35483;mdi193;MDi 193;Fluidil;Doburil;Aquirel;Aquador;Anhydron;Renazide

CBNumber:: CB6123851

Molecular Formula:: C14H16ClN3O4S2

Molecular Weight:: 389.88

MOL File:: 2259-96-3.mol

Modify Date:: 2023/6/30 15:45:59

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CYCLOTHIAZIDE Properties

Melting point	234°
Density	1.3781 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
pka	pKa 9.1(30% EtOH) (Uncertain)
form	White to off-white solid.
color	Off-white
λmax	273nm(lit.)
Merck	14,2754
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
EPA Substance Registry System	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H319-H315

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

DK9610000

HS Code

2935904000

Toxicity

LD50 oral in rat: > 5gm/kg

NFPA 704

	0
2		0

CYCLOTHIAZIDE price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C9847	Cyclothiazide	2259-96-3	10MG	₹13195.68	2022-06-14	Buy
Sigma-Aldrich(India)	C9847	Cyclothiazide	2259-96-3	25MG	₹27127.45	2022-06-14	Buy
TCI Chemicals (India)	C3392	Cyclothiazide (mixture of isomers)	2259-96-3	25MG	₹5000	2022-05-26	Buy
TCI Chemicals (India)	C3392	Cyclothiazide (mixture of isomers)	2259-96-3	100MG	₹12500	2022-05-26	Buy

Product number	Packaging	Price	Buy
C9847	10MG	₹13195.68	Buy
C9847	25MG	₹27127.45	Buy
C3392	25MG	₹5000	Buy
C3392	100MG	₹12500	Buy

CYCLOTHIAZIDE Chemical Properties,Uses,Production

Uses

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.

Definition

ChEBI: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension a d oedema.

General Description

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.

Biological Activity

Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .

CYCLOTHIAZIDE Preparation Products And Raw materials

Raw materials

4-Amino-6-chlorobenzene-1,3-disulfonamide

Preparation Products

CYCLOTHIAZIDE Suppliers

Global( 92)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Alfa Chemistry	+1-5166625404	United States	21317	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	China	9003	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
career henan chemical co	58
Alfa Chemistry	58
InvivoChem	58
Shaanxi Didu New Materials Co. Ltd	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58

2259-96-3(CYCLOTHIAZIDE)Related Search:

(RS)-AMPA Comphene Chlorothiazide Camphene Aminomethylcyclopentane hydrochloride

Hydrochlorothiazide butizide mebutizide CYCLOTHIAZIDE CLOFENAMIDE

2-amino-N-propylbenzenesulfonamide 4-Amino-6-chlorobenzene-1,3-disulfonamide ethiazide 2-AMINO-N-METHYLBENZENESULFONAMIDE N-(5-NORBORNENE-2-METHYL)-METHANESULFONAMIDE

2-AMINO-N-BUTYLBENZENESULFONAMIDE 4-CHLORO-1,3-BENZENEDITHIOL Benzenesulfonamide, 2-(methylamino)- (9CI)

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7-sulfonamide1,1-dioxide Anhydron Aquirel Doburil Fluidil Lilly 35483 lilly35,483 MDi 193 Cyclothiazide (200 mg) (AS) Lil 3-((1S,4S)-bicyclo[2.2.1]hept-5-en-2-yl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonaMide 1,1-dioxide 2,4-benzothiadiazine-3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-4-dihydro-2h-1 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-chloro-3-(5-norbornen-2-yl)-,1,1-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-bicyclo(2.2.1)hept-5-en-2-yl-6-chlor 35483 4-benzothiadiazine-7-sulfonamide,3,4-dihydro-6-chloro-3-(5-norbornen-2-2h-2 mdi193 o-3,4-dihydro-,1,1-dioxide Renazide Valmiran CYCLOTHIAZIDE 3-BICYCLO[2.2.1]HEPT-5-EN-2-YL-6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-CHLORO-3,4-DIHYDRO-3-[2-NORBORNEN-5-YL]-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 6-CHLORO-3,4-DIHYDRO-3-(5-NORBORNEN-2-YL)-2H-1,2,4-BENZOTHIAZIDIAZINE-7-SULFONAMIDE-1,1-DIOXIDE 6-CHLORO-3,4-DIHYDRO-3-(NORBORNER-5-YL)-2H-1,2,4-BENZOTHIADIAZINE 6-CHLORO-3,4-DIHYDRO-3-(NORBORNER-5-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULPHONAMIDE-1,1-DIOXIDE 6-chloro-3,4-dihydro-3-(8,9,10-trinorborn-5-en-2-yl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide Anhydrom Aquador 3-(6-bicyclo[2.2.1]hept-2-enyl)-6-chloro-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 3-(6-bicyclo[2.2.1]hept-2-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-3-(5-norbornen-2-2h-2 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2h-1,2,4-benzothiadiazine-7-sulfonam 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-7-sulfamoyl-1,2,4-benzothiadiazine1, 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide CYCLOTHIAZIDE USP/EP/BP Cyclothiazide (AS) (1159008) Cyclothiazide (mixture of isomers) Inhibitor,neurones,iGluR,AMPA receptor desensitization,current potentiation,Cyclothiazide,Ionotropic glutamate receptors,positive allosteric modulator,inhibit Cyclothiazide (200 mg) (AS) (DISCONTINUED) 2259-96-3 C14H16ClN3O4S2 C14H16N3O4S2Cl Cell Signaling and Neuroscience Cell Biology BioChemical Ligand-Gated Ion Channels Ionotropic Glutamate Receptor Modulators Ion Channels Glutamate Glutamate receptor Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals