p-Coumaric acid
- CAS No.
- 501-98-4
- Chemical Name:
- p-Coumaric acid
- Synonyms
- TRANS-4-HYDROXYCINNAMIC ACID;trans-p-Hydroxycinnamic acid;(E)-3-(4-hydroxyphenyl)acrylic acid;p-CouMaric;TRANS-4-COUMARIC ACID;TRANS-P-COUMARIC ACID;(E)-p-Coumaric acid;PHCA;Naringeninic acid;(e)-p-coumaricacid
- CBNumber:
- CB6164395
- Molecular Formula:
- C9H8O3
- Molecular Weight:
- 164.16
- MOL File:
- 501-98-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/10 10:44:54
| Melting point | 214 °C (dec.)(lit.) |
|---|---|
| Boiling point | 231.61°C (rough estimate) |
| Density | 1.1403 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | ethanol: soluble50mg/mL |
| form | Powder |
| pka | 4.65±0.10(Predicted) |
| color | Off-white to beige or greenish |
| Odor | at 100.00?%. balsamic |
| Water Solubility | soluble |
| Merck | 14,2560 |
| BRN | 2207383 |
| Stability | Light Sensitive |
| InChIKey | NGSWKAQJJWESNS-ZZXKWVIFSA-N |
| LogP | 1.460 |
| CAS DataBase Reference | 501-98-4(CAS DataBase Reference) |
| NIST Chemistry Reference | p-Hydroxycinnamic acid(501-98-4) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GD9095000 | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
p-Coumaric acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C9008 | p-Coumaric acid ≥98.0% (HPLC) | 501-98-4 | 1G | ₹2056.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9008 | p-Coumaric acid ≥98.0% (HPLC) | 501-98-4 | 5G | ₹3215.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9008 | p-Coumaric acid ≥98.0% (HPLC) | 501-98-4 | 10G | ₹5748.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C9008 | p-Coumaric acid ≥98.0% (HPLC) | 501-98-4 | 25G | ₹10435.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 55823 | trans-p-Coumaric acid analytical standard | 501-98-4 | 50MG | ₹6386.75 | 2022-06-14 | Buy |
p-Coumaric acid Chemical Properties,Uses,Production
Chemical Properties
Off-white to beige or greenish powder. Soluble in alcohol, ether and hot water, slightly soluble in benzene, insoluble in petroleum ether.
Definition
ChEBI: p-coumaric acid is the trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.
Preparation
Synthesis of p-Coumaric acid: take o-acetylsalicyloyl chloride as raw material, in the presence of magnesium chloride, react with diethyl malonate in acetonitrile solvent, then add triethylamine, and react at 0°C for 1 h to obtain ( 2-acetoxybenzoyl) diethyl malonate product, then heated to 50°C in potassium hydroxide/methanol solution, reacted for 3h, and cyclized to obtain p-Coumaric acid.
Application
trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. It has been used as a component of chemiluminescent substrate for protein detection in western blotting.
Purification Methods
Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.]
p-Coumaric acid Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SREE SYNERIC LAB | +91-91-6383636810 +91-9884742764 | Tamil Nadu, India | 465 | 58 | Inquiry |
| DHANVI EXIM SERVICES | +91-8790148237 +91-8790148237 | Hyderabad, India | 162 | 58 | Inquiry |
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
| Supplier | Advantage |
|---|---|
| SREE SYNERIC LAB | 58 |
| DHANVI EXIM SERVICES | 58 |
| Dr. Jagath Reddy's Heterocyclics | 42 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| PEE ESS AROMATICS | 30 |
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