Imazameth
- CAS No.
- 104098-48-8
- Chemical Name:
- Imazameth
- Synonyms
- CADRE;IMAZAPI;IMAZAPIC;IMAZAMETH;Imazapic 70%WG;AC 263, 222(TM);imazapic(bsi,iso);Imazapic, Pestanal;C14282500 Imazapic;Pirarubicine Impurity 9
- CBNumber:
- CB6354097
- Molecular Formula:
- C14H17N3O3
- Molecular Weight:
- 275.3
- MOL File:
- 104098-48-8.mol
- Modify Date:
- 2024/11/13 11:39:26
| Melting point | 205-207°C |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated) |
| pka | 10.72±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| LogP | 2.470 |
| CAS DataBase Reference | 104098-48-8(CAS DataBase Reference) |
| EPA Substance Registry System | Imazapic (104098-48-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400-H410 |
| Precautionary statements | P273-P391-P501-P273-P391-P501 |
| WGK Germany | 3 |
| RTECS | US7079100 |
| HS Code | 29333990 |
Imazameth Chemical Properties,Uses,Production
Uses
Imazapic is registered throughout the world for use in peanuts, rangeland, sugarcane, and imidazolinoneresistant canola (12). A nonionic surfactant or oil adjuvant is required for maximum activity.
Pharmacology
Imazapic kills plants by inhibiting acetolactate synthase (ALS) (I50 = 1 μM), which is the first common enzyme in the biosynthesis of the branched chain amino acids, valine, leucine, and isoleucine. Imazapic is rapidly absorbed through the leaves of plants. Once it enters the plant, imazapic translocates to the growing points and growth ceases within 1 day after herbicide application followed by chlorosis and then necrosis of the growing points. Total plant death will occur within 2 to 3 weeks after treatment.
Environmental Fate
Imazapic is weakly to moderately adsorbed on sandy loam and silt loam soils. The Freundlich adsorption coefficient ranges from 0.17 to 2.99, (12). Because imazapic is a weak acid and exists in different ionic states, soil pH has an effect on soil binding properties. The anionic form predominates at soil pH as low as 5.5, and this form binds weakly to soil. The neutral or molecular form is important at soil pH from 4 to 6.5. This form binds to soil organic matter and clay. The cationic form is important at pH less than 4. Because the soil is a heterogeneous mixture of acid and base chemical groups, there may be sites within a particular soil that are 2 to 3 pH units higher or lower than the average pH. The cationic form will bind tightly to the lower pH components. Because of these interactions, small decreases in pH below 6 will result in large increases in binding. The half-life of imazapic in the soil is 106 d. Imazapic remains in the top 30 cm of the soil with low leaching potential. The degradation route of imazapic in the soil has not been determined.
Metabolism
Plant Metabolism. The selectivity of imazapic is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds(10). Imazapic
has excellent selectivity in peanuts, but is not selective in
soybeans. The difference in the tolerance of these two
legumes is due to the different routes of metabolism
of imazapic in the two crops. The primary metabolite
in soybeans is an imidazopyrrolo-pyridine derivative,
whereas in peanuts, the primary metabolite is the
glucose conjugate of hydroxy-imazapic. Although the
imidazopyrrolo-pyridine derivative formed in soybean is
immobile and is not an inhibitor of acetolactate synthase,
the rate of degradation of imazapic in soybeans is not rapid
enough for selectivity (10). In imidazolinone-resistant
crops, the primary mechanism of selectivity is due to
an altered acetolactate synthase that is not inhibited by
the imazapic (11).
Animal Metabolism (12). Metabolism studies in the rat
showed that imazapic is rapidly excreted in the urine.
There was no accumulation of imazapic or any of its
derivatives in the liver, kidney, muscle, fat, or blood.
Imazameth Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12840 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | China | 18154 | 58 | Inquiry |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | China | 341 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | China | 1178 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21634 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | China | 9215 | 55 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | China | 6383 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49374 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29811 | 58 | Inquiry |
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