Imazapyr acid
- CAS No.
- 81334-34-1
- Chemical Name:
- Imazapyr acid
- Synonyms
- IMAZAPYR;Imazapyr 98% TC;Charper;AC-243997;CL 252925;AC 252925;Imazapire;ARSENAL(R);Arsenal(TM);Arsenal 250A
- CBNumber:
- CB7121753
- Molecular Formula:
- C13H15N3O3
- Molecular Weight:
- 261.28
- MOL File:
- 81334-34-1.mol
- Modify Date:
- 2024/4/1 18:08:31
| Melting point | 169-173°C |
|---|---|
| Boiling point | 404.53°C (rough estimate) |
| Density | 1.1923 (rough estimate) |
| vapor pressure | 0-0Pa at 20-25℃ |
| refractive index | 1.5600 (estimate) |
| storage temp. | 0-6°C |
| pka | 1.9, 3.6(at 25℃) |
| BRN | 5442754 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | -3.97-0.04 at 20℃ and pH3-9.9 |
| Dissociation constant | 1.7-11.1 at 20℃ |
| CAS DataBase Reference | 81334-34-1(CAS DataBase Reference) |
| EPA Substance Registry System | Imazapyr (81334-34-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36-52/53 |
| Safety Statements | 26-61 |
| WGK Germany | 2 |
| RTECS | US5682500 |
| HS Code | 29333990 |
| Toxicity | LD50 orally in rats: >5000 mg/kg; dermally in rabbits: >2000 mg/kg (Paxman) |
Imazapyr acid Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Imazapyr is an analytical standard used for proteomics research.
Pharmacology
Imazapyr kills plants by inhibiting acetolactate synthase (ALS) (I50 = 5 μM), which is the first common enzyme in the biosynthesis of the branched chain amino acids, valine, leucine, and isoleucine. Imazapyr is rapidly absorbed through the leaves of plants. Once it enters the plant, imazapyr rapidly translocates to the growing points and growth ceases within 1 day after herbicide application followed by chlorosis and then necrosis of the growing points. Total plant death will occur within 2 to 3 weeks after treatment.
Environmental Fate
Imazapyr is weakly to moderately adsorbed on sandy loam and silt loam soils. The Freundlich adsorption coefficient ranges from 0 to 7.8 (15). Because imazapyr is a weak acid and exists in different ionic states, soil pH has an effect on soil binding properties. The anionic form predominates at soil pH as low as 5.5, and this form bindsweakly to soil. The neutral or molecular form is important at soil pH from 4 to 6.5. This form binds to soil organic matter and clay. The cationic form is important at pH less than 4. Because the soil is a heterogeneous mixture of acid and base chemical groups, there may be sites within a particular soil that are 2 to 3 pH units higher or lower than the average pH. The cationic form will bind tightly to the lower pH components. Because of these interactions, small decreases in pH below 6 will result in large increases in binding. The half-life of imazapyr in the soil is 25–142 d (14). Imazapyr remains in the top 30 cm of the soil with low leaching potential. The degradation route of imazapyr in the soil has not been determined.
Metabolism
Plant Metabolism. The selectivity of imazapyr is due to
differential rates and routes of metabolism in tolerant
crops versus susceptible weeds (3). The half-life
of imazapyr in tolerant crops has not been accurately
determined. The metabolic route of imazapyr is not clear.
The parent compound can be metabolized to a tricyclic
compound (33, Fig. 15) in some species, but the primary
metabolite is an imidazopyrrolo-pyridine derivative (34,
Fig. 15). This compound does not inhibit acetolactate
synthase, the target site for the imidazolinones, and it
is immobile in the plant (4).
Animal Metabolism. Metabolism studies in the rat
showed that imazapyr is rapidly excreted in the urine (5).
There was no accumulation of imazapyr or any of its
derivatives in the liver, kidney, muscle, fat, or blood.
Imazapyr acid Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
| airuikechemical co., ltd. | +undefined86-15315557071 | China | 983 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
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