QUINOMYCIN A

CAS No.: 512-64-1

Chemical Name:: QUINOMYCIN A

Synonyms: SK-302B;nsc526417;NSC 13502;ECHINOMYCIN;echinomycina;QUINOMYCIN A;Echinomycin >97%;Antibiotic A 654I;Echinomycin (NSC-13502);EchinoMycin, Actinoleukin, 1491, 59266, X 948, X 53III

CBNumber:: CB6394145

Molecular Formula:: C51H64N12O12S2

Molecular Weight:: 1101.26

MOL File:: 512-64-1.mol

MSDS File:: SDS

Modify Date:: 2023/7/14 17:45:39

Request For Quotation

QUINOMYCIN A Properties

Melting point	217-218℃
alpha	D20 -310° (c = 0.86 in chloroform)
Boiling point	1427.2±65.0 °C(Predicted)
Density	1.0964 (rough estimate)
refractive index	1.6700 (estimate)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 5 mg/ml)
pka	9.38±0.70(Predicted)
form	White solid
color	white to beige
Merck	13,3531
Stability	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311+H331-H361

Precautionary statements

P201-P202-P280-P301+P310-P302+P352+P312-P304+P340+P311

Hazard Codes

Risk Statements

46-23/24/25

Safety Statements

53-36/37/39-45

RIDADR

UN 3462 6.1/PG 2

WGK Germany

RTECS

JW5250000

HazardClass

6.1(b)

PackingGroup

III

HS Code

2941900000

NFPA 704

	0
4		0

QUINOMYCIN A price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0477	Echinomycin ≥98% (HPLC)	512-64-1	1MG	₹13996.73	2022-06-14	Buy
Sigma-Aldrich(India)	SML0477	Echinomycin ≥98% (HPLC)	512-64-1	5MG	₹59526.68	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0477	1MG	₹13996.73	Buy
SML0477	5MG	₹59526.68	Buy

QUINOMYCIN A Chemical Properties,Uses,Production

Description

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC₅₀ value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.

Uses

Quiniomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumour agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumour progression and metastasis.

Biochem/physiol Actions

Echinomycin is an antitumor antibiotic and potent hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the binding of HIF-1α, a transcription factor important in tumor growth. Echinomycin selectively eliminated cancer stem cells in a study with mouse lymphoma and human AML xenogeneic models, eradicating the lymphomas. Recently, echinomycin was also found to act as an antibiotic adjuvant having synergistic effects with novobiocin in gram negative bacteria.

QUINOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

QUINOMYCIN A Suppliers

Global( 65)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	4088	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Nextpeptide Inc	+86-0571-81612335 +8613336028439	China	19915	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	China	2971	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Nextpeptide Inc	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58

512-64-1(QUINOMYCIN A)Related Search:

Chrysin Anifostine trihydrate CHAETOMIN BISPHENOL A DIMETHYL ETHER Sunitinib Malate

Geldanamycin Imatinib mesylate Azithromycin 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 2-QUINOXALINECARBALDEHYDE

AC-VAL-OME QUINOMYCIN A DIMETHYLAMINOETHOXY PROPYLAMINE quinomycin N,N-DIMETHYL-L-VALINE

2-QUINOXALINYLMETHYLAMINE,97% 2-Quinoxalinemethanamine,N-methyl-(9CI) 3-[(3-AMINO-3-OXOPROPYL)THIO]PROPANAMIDE

chevron_left

1of4

chevron_right

echinomycina nsc526417 ECHINOMYCIN N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-) SK-302B Echinomycin >97% N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester Echinomycin (NSC-13502) QUINOMYCIN A EchinoMycin, Actinoleukin, 1491, 59266, X 948, X 53III 9,22-Dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane cyclic peptide deriv. Antibiotic A 654I NSC 13502 Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether N-[2,4,12,15,17,25-hexamethyl-29-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-7-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-20-yl]quinoxaline-2-carboxamide L-Valine, N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-, (8→1)-lactone, cyclic (3→7)-thioether 512-64-1 C51H64N12O12S2 Antibiotics Antibiotics A-F Antibiotics A to Z BioChemical Antitumour Antibiotic