Crotamiton
- CAS No.
- 483-63-6
- Chemical Name:
- Crotamiton
- Synonyms
- N-ETHYL-O-CROTONOTOLUIDIDE;Eurax;Crotalgin;n-ethyl-n-(2-methylphenyl)-butenamide;Euraxil;Eurasil;Veteusan;Crotamtex;Vet-eusan;Clomitone
- CBNumber:
- CB6451611
- Molecular Formula:
- C13H17NO
- Molecular Weight:
- 203.28
- MOL File:
- 483-63-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:14
| Melting point | 25°C |
|---|---|
| Boiling point | 153-155 °C/13 mmHg (lit.) |
| Density | 0.987 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble |
| pka | 1.14±0.50(Predicted) |
| form | <25°C Solid,>25°C Liquid |
| color | Colourless to Light Brown |
| Water Solubility | Soluble in water (1:500), alcohol, methanol, ether, and ethanol. |
| Merck | 13,2622 |
| Stability | Light Sensitive |
| InChIKey | DNTGGZPQPQTDQF-XBXARRHUSA-N |
| LogP | 3.099 (est) |
| CAS DataBase Reference | 483-63-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Crotamiton(483-63-6) |
| EPA Substance Registry System | Crotamiton (483-63-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/38-43 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GQ7000000 | |||||||||
| HS Code | 2924296000 | |||||||||
| NFPA 704 |
|
Crotamiton Chemical Properties,Uses,Production
Description
Crotamiton is available as a 10% cream for the treatment of scabies, although it is less effective than pyrethrins or permethrin. Because crotamiton may need to be applied a second time for successful treatment of scabies but the pyrethrins or permethrin require a single application, poor patient compliance with crotamiton may reduce its effectiveness. The advantage of crotamiton over lindane comes from the fact that lindane has potential neurotoxicity if absorbed especially in infants and children, whereas crotamiton has less systemic neurotoxicity.
Chemical Properties
N-Ethyl-o-crotonotoluidide is colourless or pale yellow, oily liquid
Uses
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.
Indications
Crotamiton (N-ethyl-o-crotonotoluide, Eurax) is a synthetic chloroformate salt used
for the prevention and treatment of scabies, although cure rates tend to be lower
for the same number of applications compared with lindane and permethrin. It may
have an antipruritic effect independent of its scabetic effect. Its mechanism of action
is unknown. It is not effective as a pediculicide.
Crotamiton (10% N-ethyl-o-crotonotoluide, Eurax) cream applied twice and
left on during a 48-hour period is usually effective against scabies and has been
reported to act as an antipruritic agent.
Definition
ChEBI: The amide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporate from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred.
Clinical Use
N-Ethyl-N-(2-methylphenyl)-2-butenamide, or N-ethyl-ocrotonotoluidide(Eurax), is a colorless, odorless oily liquid.It is virtually insoluble in water but soluble in most organicsolvents.
Crotamiton is available in 10% concentration in a lotionand a cream intended for the topical treatment of scabies. Its antipruritic effect is probably because of a local anestheticaction.
Side effects
The most common side effect reported for crotamiton is skin irritation.
Crotamiton Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Asence Pharma Pvt Ltd | +91-265228317 +91-265228317 | Gujarat, India | 16 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Catapharma Chemicals Private Limited | 09422770877 | Maharashtra, India | 56 | 58 | Inquiry |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | China | 37 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2952 | 58 | Inquiry |
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