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Trimethyl phosphonoacetate

CAS No.: 5927-18-4

Chemical Name:: Trimethyl phosphonoacetate

Synonyms: TMPA;METHYL DIMETHYLPHOSPHONOACETATE;Methyl (dimethoxyphosphoryl)acetate;NSC 84262;TriMethyl phosphonoacetat;TRIMETHYL PHOPHONOACETATE;trimethylacetyl phosphate;Trimethylphosphoroacetate;TRIMETHYL PHOSPHONACETATE;RIMETHYL PHOSPHONOACETATE

CBNumber:: CB6726270

Molecular Formula:: C5H11O5P

Molecular Weight:: 182.11

MOL File:: 5927-18-4.mol

Modify Date:: 2024/8/21 22:41:43

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Trimethyl phosphonoacetate Properties

Melting point	242 °C
Boiling point	118 °C0.85 mm Hg(lit.)
Density	1.125 g/mL at 25 °C(lit.)
refractive index	n20/D 1.437(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
Specific Gravity	approximate 1.265ｇ/ml (20℃)
color	Clear colorless to light yellow
Water Solubility	Slightly miscible with water.
BRN	1865177
LogP	-0.680 (est)
CAS DataBase Reference	5927-18-4(CAS DataBase Reference)
NIST Chemistry Reference	Trimethyl phosphonoacetate(5927-18-4)
EPA Substance Registry System	Acetic acid, (dimethoxyphosphinyl)-, methyl ester (5927-18-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227-H315-H319-H335

Precautionary statements

P210e-P261-P280a-P305+P351+P338-P405-P501a

Safety Statements

23-24/25

WGK Germany

TSCA

Yes

HS Code

29310095

NFPA 704

	0
0		0

Trimethyl phosphonoacetate price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T79758	Trimethyl phosphonoacetate 98%	5927-18-4	25G	₹2717.08	2022-06-14	Buy
Sigma-Aldrich(India)	T79758	Trimethyl phosphonoacetate 98%	5927-18-4	100G	₹8627.53	2022-06-14	Buy
ALFA India	ALF-A13301-36	Trimethyl phosphonoacetate, 98%	5927-18-4	500g	₹24562	2022-05-26	Buy
ALFA India	ALF-A13301-22	Trimethyl phosphonoacetate, 98%	5927-18-4	100g	₹8355	2022-05-26	Buy
ALFA India	ALF-A13301-14	Trimethyl phosphonoacetate, 98%	5927-18-4	25g	₹2880	2022-05-26	Buy

Product number	Packaging	Price	Buy
T79758	25G	₹2717.08	Buy
T79758	100G	₹8627.53	Buy
ALF-A13301-36	500g	₹24562	Buy
ALF-A13301-22	100g	₹8355	Buy
ALF-A13301-14	25g	₹2880	Buy

Trimethyl phosphonoacetate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.

Application

Trimethyl phosphonoacetate is an important Wittig-horner reagent, which can be used to manufacture important intermediates of natural compounds such as vitamins, drugs, insect pheromones, etc.
Reactant involved in:
Intramolecular Mannich-type reactions to produce the sarain A diazatricyclic core
Organocatalytic oxa-Michael reactions
Prenylation and geranylation of oxindoles
Intramolecular Horner-Wadsworth-Emmons reactions
Olefin cross-metathesis / heterocyclization

Trimethyl phosphonoacetate Preparation Products And Raw materials

Raw materials

BIS(2,2,2-TRIFLUOROETHYL) (METHOXYCARBONYLMETHYL)PHOSPHONATE PHOSPHONOACETIC ACID METHYL DIAZOACETATE Methyl chloroacetate

Preparation Products

3-METHOXYCARBONYL-3-SULFOLENE (2E,4E,6Z)-methyl deca-2,4,6-trienoate (2E)-2-Nonenoic acid methyl ester METHYL TRANS-2-HEXENOATE, 98 tert-Butyl 2-(dimethoxyphosphoryl)acetate

Trimethyl phosphonoacetate Suppliers

Global( 380)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry
Litmus Organics Pvt Ltd	+91-9820378798 +91-9820378798	Maharashtra, India	8	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Central Drug House(P) Ltd.	91-11-49404040	New Delhi, India	6160	58	Inquiry
Litmus Organics Private Limited	08048371573Ext 330	Mumbai, India	4	58	Inquiry
Saradhi Organics	91-7660890360	Hyderabad, India	184	58	Inquiry

Supplier	Advantage
JSK Chemicals	58
Litmus Organics Pvt Ltd	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
Otto Chemie Pvt. Ltd.	58
Alfa Aesar	58
Central Drug House(P) Ltd.	58
Litmus Organics Private Limited	58
Saradhi Organics	58

How to synthesize Trimethyl phosphonoacetate?
Phosphoryl 3-acetic acid methyl ester is a kind of chemical substance also known as phosphine acyl acetic acid trimethyl or Tr....
Jan 23，2024

Trimethyl phosphonoacetate Spectrum

Trimethyl phosphonoacetate(5927-18-4)MS Trimethyl phosphonoacetate(5927-18-4)¹HNMR Trimethyl phosphonoacetate(5927-18-4)¹³CNMR Trimethyl phosphonoacetate(5927-18-4)IR1 Trimethyl phosphonoacetate(5927-18-4)Raman

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TriMethyl phosphonoacetate, 98% 25GR Dimethylphosphonoacetic Acid Methyl Ester Methyl Dimethylphosphonoacetate Phosphonoacetic Acid Trimethyl Ester TriMethyl phosphonoacetat Aceticacid, 2-(diMethoxyphosphinyl)-, Methyl ester Dibenzyloxyphosphoiyl three Methyl acetate (Carboxymethyl)phosphonic acid trimethyl ester Dimethyl methoxycarbonylmethylphosphonate~Phosphonoacetic acid trimethyl ester trimethylacetyl phosphate TRIMETHYL PHOPHONOACETATE Dimethyl (methoxycarbonyl)methylphosphonate, 98 % (Dimethoxyphosphinyl)acetic acid methyl 2-(Dimethoxyphosphinyl)acetic acid methyl Dimethoxyphosphinylacetic acid methyl Methoxycarbonylmethylphosphonic acid dimethyl ester (Dimethoxy-phosphoryl)-aceticacidmethylester Trimethylphosphonoacetate,98% TriMethyl phosphonoacetate, 98% 100GR NSC 84262 Dimethyl methoxycarbonylmethanephosphonate for synthesis (dimethoxyphosphinyl)-aceticacimethylester Trimethylphosphoroacetate (DIMETHOXYPHOSPHINYL)ACETIC ACID METHYL ESTER DIMETHYL METHOXYCARBONYLMETHANEPHOSPHONATE DIMETHYL (METHOXYCARBONYL)METHYLPHOSPHONATE DIMETHYLPHOSPHONOACETIC ACID METHYL ESTER ACETIC ACID, (DIMETHOXYPHOSPHINYL)-, METHYL ESTER PHOSPHONOACETIC ACID TRIMETHYL ESTER TRIMETHYL PHOSPHONACETATE TRIMETHYL PHOSPHONOACETATE Trimethylphosphonoyl acetate TrimethylPhosphonoacetate> Trimethyl phosphonoacetate, 98%, for synthesis Trimethyl phosphonylacetate RIMETHYL PHOSPHONOACETATE TMPA METHYL DIMETHYLPHOSPHONOACETATE Methyl (dimethoxyphosphoryl)acetate Phosphonyl acetate trimethyl ester 5927-18-4 CH3O2POCH2CO2CH3 C5H11O5P Horner-Wadsworth-Emmons Reagents Olefination Synthetic Reagents Wittig & Horner-Emmons Reaction Horner-Emmons Reaction C-C Bond Formation Horner-Emmons Reaction Synthetic Organic Chemistry Wittig & Horner-Emmons Reaction C-C Bond Formation Horner-Wadsworth-Emmons Reagents Olefination 5927-18-4