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Hydroxychloroquine

Hydroxychloroquine Structure
CAS No.
118-42-3
Chemical Name:
Hydroxychloroquine
Synonyms
hydroxychloroquine;plaquenil;C07043;win1258;Oxychlorochin;Oxychloroquine;Oxichloroquine;Hydroychloroquine;Hydroxychloroquine base;Hydroxychloroquine sulfuric acid
CBNumber:
CB6866802
Molecular Formula:
C18H26ClN3O
Molecular Weight:
335.88
MOL File:
118-42-3.mol
MSDS File:
SDS
Modify Date:
2024/5/21 21:51:03
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Hydroxychloroquine Properties

Melting point 89-91°
Boiling point 516.7±50.0 °C(Predicted)
Density 1.1438 (rough estimate)
refractive index 1.5790 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightlly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 14.76±0.10(Predicted)
color White to Off-White
BCS Class 2
NIST Chemistry Reference Hydroxychloroquine(118-42-3)
EPA Substance Registry System Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]- (118-42-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P261-P264-P270-P272-P280-P301+P312+P330-P302+P352-P333+P313-P363-P501
Toxicity child,LDLo,oral,600mg/kg (600mg/kg),BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSUREBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDCARDIAC: OTHER CHANGES,Journal of Analytical Toxicology. Vol. 14, Pg. 186, 1990.

Hydroxychloroquine Chemical Properties,Uses,Production

Uses

Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, in addition to malaria.
Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.
Hydroxychloroquine is used to treat:
rheumatoid arthritis
discoid and systemic lupus erythematosus (SLE)
juvenile idiopathic arthritis (JIA).
Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits.

Indications

Hydroxychloroquine (Plaquenil), like chloroquine, is a 4-aminoquinoline derivative used for the suppressive and acute treatment of malaria. It also has been used for rheumatoid arthritis and discoid and systemic lupus erythematosus. Hydroxychloroquine has not been proved to be more effective than chloroquine. Adverse reactions associated with its use are similar to those described for chloroquine.The drug should not be used in patients with psoriasis or porphyria, since it may exacerbate these conditions.

Definition

ChEBI: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used s the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.

Mechanism of action

Hydroxychloroquine, like chloroquine, is also used for treating acute forms of malaria caused by P. vivax, P. malariae, P. ovale, and also sensitive forms of P. falciparum. It is also effective and safe like chloroquine, although it does not have obvious advantages. The only advantage is that it is somewhat better tolerated. Its use is somewhat more limited than chloroquine. Synonyms of this drug are plaquenil, quensyl, toremonil, and others.

Clinical Use

Hydroxychloroquine is approved for the treatment of both systemic and cutaneous lupus erythematosus. Both chloroquine and quinacrine (Atabrine) are also effective in this skin disease. Low-dose chloroquine is used for the therapy of porphyria cutanea tarda in patients in whom phlebotomy has failed or is contraindicated. Other skin diseases in which the drugs are useful (after sunscreens and avoidance of sun exposure) include polymorphous light eruption and solar urticaria.

Hydroxychloroquine Preparation Products And Raw materials

Raw materials

Sulfuric acid Hydrogen 2-(Ethylamino)ethanol Ammonia 5-Chloro-2-pentanone
4,7-Dichloroquinoline Phosphoric acid 7-CHLORO-4-FLUOROQUINOLINE 2,3-DICHLOROQUINOLINE 2-(4-Aminopentyl(ethyl)amino)ethanol
2-Pentanone, 5-iodo- 5-[ethyl(2-hydroxyethyl)amino]pentan-2-one 2-Acetylbutyrolactone
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Preparation Products

Hydroxychloroquine Suppliers

Global( 170)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Orgamine Chemicals(I) Pvt Ltd +91-9820080281 +91-9820080281 Maharashtra, India 451 58 Inquiry
Venkatasai Life Sciences +91-9908134868 +91-8008303069 Hyderabad, India 186 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Indexim International 08048971004 Gujarat, India 112 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Supplier Advantage
Varanous Labs Pvt Ltd 58
HRV Global Life Sciences 58
Orgamine Chemicals(I) Pvt Ltd 58
Venkatasai Life Sciences 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Triveni chemicals 58
Indexim International 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58

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