Midostaurin

CAS No.: 120685-11-2

Chemical Name:: Midostaurin

Synonyms: QTH113;CS-730;PKC412A;PKC 412A;PKC-412A;CGP 41231;Cgp 41251;Cgp-41251;Cgp 41 251;midostaruin

CBNumber:: CB71315281

Molecular Formula:: C35H30N4O4

Molecular Weight:: 570.64

MOL File:: 120685-11-2.mol

Modify Date:: 2024/5/23 14:47:35

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Midostaurin Properties

Melting point	235-260℃
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
pka	14.19±0.70(Predicted)
form	Tan solid
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H360FD

Precautionary statements

P201-P202-P280-P308+P313-P405-P501

Hazard Codes

Risk Statements

36/37/38

HS Code

29329990

NFPA 704

	0
2		0

Midostaurin price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	539648	Staurosporine, N-Benzoyl A cell-permeable Staurosporine derivative that displays antitumor properties.	120685-11-2	1MG	₹21460	2022-06-14	Buy

Product number	Packaging	Price	Buy
539648	1MG	₹21460	Buy

Midostaurin Chemical Properties,Uses,Production

Definition

ChEBI: An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.

brand name

Rydapt

General Description

Class: receptor tyrosine kinase; Treatment: AML, SM; Other name: PKC-412, CGP41251; Elimination half-life = 20 h; Protein binding > 99%

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( α , β , γ ), PDFR β , VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

target

Primary targets: FLT3, KIT

Midostaurin Preparation Products And Raw materials

Raw materials

Preparation Products

Midostaurin Suppliers

Global( 227)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
Dr. Reddy's Laboratories Ltd	+91-4049002900 +91-4049002900	Hyderabad, India	165	58	Inquiry
Apicore Pharmaceuticals Pvt Ltd	+91-2662267177 +91-2662267166	Gujarat, India	181	58	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	470	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
CONCORD BIOTECH LTD	+91 79 68138700	New Delhi, India	18	58	Inquiry
DR REDDYS LABORATORIES LTD	+91-40-49002900	New Delhi, India	201	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
Dr. Reddy's Laboratories Ltd	58
Apicore Pharmaceuticals Pvt Ltd	58
AKASH PHARMA EXPORTS	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
CONCORD BIOTECH LTD	58
DR REDDYS LABORATORIES LTD	58

Midostaurin Spectrum

Midostaurin(120685-11-2)¹HNMR

120685-11-2(Midostaurin)Related Search:

CYCLOPAMINE Cantharidin Troglitazone ZM 447439 CGP52421

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Epothilone D Ibrutinib

CARBAZOL-9-YL-METHANOL 9-ISOPROPYLCARBAZOLE 11,12-Dihydroindolo[2,3-a]carbazole Midostaurin K-252C

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CGP 41251MIDOSTAURIN(PKC412) N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide PKC-412, CGP-41251 Midostaurin (PKC412) PKC412 (Midostaurin) CGP 41231 N-Benzoylstaurosporine (Midostaurin) Benzoylstaurosporine midostaruin 4'-N-benzoylstaurosporine Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251 Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-J)(1,7)benzodiazonin-11-yl)-N-methyl- Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7B,12A-triazadibenzo(A,G)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)- Benzoylstaurosporine Cgp 41 251 Cgp 41251 Cgp-41251 Midostaurin Midostaurin [inn] [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide PKC412 CGP 41231 CGP 41251 Midostaurin Benzoylstaurosporine Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- Midostaurin USP/EP/BP Midaustorin N-((5S,6R,7R,9S)-6-Methoxy-5-methyl-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide PKC412(Midostaurin,CGP41231,CGP41251) PKC412 from Staurosporine QTH113 Staurosporine, N-Benzoyl MIDOSTAURIN; CGP-41251; PKC-412; PKC412;PKC 412 CS-730 MIDOSTAURIN (PKC412; CGP 41251) Midoridoline N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide Midostaurin (Amorphous and Form II) N-((5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide PKC 412A PKC412A PKC-412A Midostaurin Impurity 120685-11-2 20685-11-2 C35H30N4O4 C325H30N4O4 antibiotic Pharmaceutical