2-Methoxy-5-sulfamoylbenzoic acid
- CAS No.
- 22117-85-7
- Chemical Name:
- 2-Methoxy-5-sulfamoylbenzoic acid
- Synonyms
- Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
- CBNumber:
- CB7354418
- Molecular Formula:
- C8H9NO5S
- Molecular Weight:
- 231.23
- MOL File:
- 22117-85-7.mol
- Modify Date:
- 2023/10/27 18:28:04
| Melting point | 220 °C |
|---|---|
| Boiling point | 482.5±55.0 °C(Predicted) |
| Density | 1.492±0.06 g/cm3(Predicted) |
| storage temp. | Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.56±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 22117-85-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Uses,Production
Uses
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
Preparation
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shreyaa Medilife Private Limited | +91-6354474696 +91-9879513108 | Ahmedabad, India | 67 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Medvance Solution | 91-9000487586 | Hyderabad, India | 137 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Medkem Laboratories | 91-40-23700606 | Andhra Pradesh, India | 297 | 58 | Inquiry |
| Synthink Research Chemicals | 09158051123 | Pune, India | 398 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Shreyaa Medilife Private Limited | 58 |
| Reax Chemicals | 58 |
| Pharma Affiliates | 58 |
| Medvance Solution | 58 |
| Clearsynth Labs | 58 |
| Medkem Laboratories | 58 |
| Synthink Research Chemicals | 58 |
| OCEAN TRADING CORPORATION | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |